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Merck

Synthesis and antifungal activity of benzofuran-5-ols.

Bioorganic & medicinal chemistry letters (2010-09-21)
Chung-Kyu Ryu, Ae Li Song, Jung Yoon Lee, Jung An Hong, Joo Hee Yoon, Aram Kim
ABSTRACT

Benzofuran-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many benzofuran-5-ols showed good antifungal activity. The results suggest that benzofuran-5-ols would be promising antifungal agents.

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Sigma-Aldrich
5-Fluorocytosine, nucleoside analog
Sigma-Aldrich
2,5-Dimethyl-1,4-benzoquinone, ≥98.0%