- Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Probing myo-inositol 1-phosphate synthase with multisubstrate adducts.
Organic & biomolecular chemistry (2012-11-08)
Rania M Deranieh, Miriam L Greenberg, Pierre-B Le Calvez, Maura C Mooney, Marie E Migaud
PMID23132282
ABSTRACT
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
MATERIALI
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Descrizione del prodotto
Sigma-Aldrich
D-sorbitolo, ≥98% (GC), BioReagent, suitable for cell culture, suitable for plant cell culture
D-sorbitolo, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
Sorbitol F solution, 70 wt. % in H2O, Contains mainly D-sorbitol with lesser amounts of other hydrogenated oligosaccharides