- Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones.
Synthesis and biological activity against Trypanosoma cruzi of substituted 1,4-naphthoquinones.
European journal of medicinal chemistry (2013-01-03)
Adriano Olímpio da Silva, Rosangela da Silva Lopes, Ricardo Vieira de Lima, Camila Santos Suniga Tozatti, Maria Rita Marques, Sérgio de Albuquerque, Adilson Beatriz, Dênis Pires de Lima
PMID23279867
ABSTRACT
The discovery and development of essential drugs for Chagas disease is a major concern worldwide. New substituted 1,4-naphthoquinones were synthesized and tested against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease. These products exhibited substantial activity against T. cruzi, especially 2-((8E,11Z)-heptadeca-8,11-dienyl)-3-hydroxynaphthalene-1,4-dione (9) with IC(50) of 7.8 μM.