Enantioseparation of benzazoles and benzanilides on polysaccharide-based chiral columns.

The chiral recognition ability of the polysaccharide-based chiral columns (Chiralpak AD-RH, Chiralpak AS-RJ, Chiralpak IC, Chiralcel OD-RH, and Chiralcel OJ-RH) for the benzazoles and the benzanilides was evaluated under reversed phase conditions. The columns showed the high chiral recognition ability for a wide range of benzazoles and benzanilides. Twenty-one racemates were used for the evaluation, and 20 racemates were completely separated on at least one of the columns. In particular, AS-RH and OJ-RH showed the high chiral recognition ability for the benzazoles, and the AD-RH, IC, and OJ-RH were effective for the benzanilides.