- The calmodulin antagonist W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) inhibits DENV infection in Huh-7 cells.
The calmodulin antagonist W-7 (N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride) inhibits DENV infection in Huh-7 cells.
Virology (2016-12-13)
Patricia Bautista-Carbajal, Ruben Soto-Acosta, Antonio H Angel-Ambrocio, Margot Cervantes-Salazar, Circe I Loranca-Vega, Mayra Herrera-Martínez, Rosa M Del Angel
PMID27940224
ABSTRACT
Dengue virus (DENV) replicative cycle occurs in the endoplasmic reticulum where calcium ions play an important role in cell signaling. Calmodulin (CaM) is the primary sensor of intracellular Ca
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