ADORA2A
adenosine A2a receptor
Synonyma:
A2aR, ADORA2, RDC8
Druh:
Human ADORA2A (135), Mouse Adora2a (11540), Rat Adora2a (25369), chicken ADORA2A (427705), naked mole-rat Adora2a (101718082), domestic guinea pig Adora2a (100135473), sheep ADORA2A (101112926), cow ADORA2A (617828), Horse ADORA2A (100034039), domestic cat ADORA2A (101080742)
ID sady UniProtKB:
ID genu:
- Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
- Mouse(11540) adenosine A2a receptor
- Rat(25369) adenosine A2a receptor
- chicken(427705) adenosine A2a receptor
- naked mole-rat(101718082) adenosine A2a receptor
- domestic guinea pig(100135473) adenosine A2a receptor
- sheep(101112926) adenosine A2a receptor
- cow(617828) adenosine A2a receptor
- Horse(100034039) adenosine A2a receptor
- domestic cat(101080742) adenosine A2a receptor
- dog(403960) adenosine A2a receptor
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Small Molecule - Agonist
Číslo produktu
Popis
Druh
Small Molecule - Antagonist
Antibodies
Číslo produktu
Popis
Druhová reaktivita
Aplikace
Anti-Adenosine A2a Receptor Antibody, Chemicon®, from rabbit,
Druhová reaktivita
bovine, canine, human, pig
Aplikace
ELISA
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2, clone 7F6-G5-A2, Upstate®, from mouse,
Druhová reaktivita
canine, dog, human, mouse, rabbit, rat
Aplikace
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Adenosine A2a Receptor Antibody, serum, Chemicon®,
Druhová reaktivita
bovine, canine, human, pig, rat
Aplikace
ELISA
western blot
western blot
Anti-ADORA2A, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Druhová reaktivita
human
Aplikace
immunohistochemistry
Small Molecule - Inhibitor
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Popis
Druh
Small Molecule - Ligand
Small Molecule - Mixed Agonist/Antagonist
Číslo produktu
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Druh
2-Fluoroadenine-9-β-D-arabinofuranoside, DNA synthesis and methylation inhibitor,
Druh
rat, human