- Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug.
Topical delivery of dexamethasone acetate from hydrogel containing nanostructured liquid carriers and the drug.
Archives of pharmacal research (2015-05-06)
Nguyen-Thach Tung, Vu-Thu Huyen, Sang-Cheol Chi
PMID25940221
RÉSUMÉ
The potential of hydrogel containing nanostructured lipid carriers (NLC) to enhance the skin permeation rate and skin deposition of dexamethasone acetate (DEA) was investigated. The particle size of obtained NLCs was around 224.4 nm. NLCs had core-shell structure and DEA existed in amorphous state in NLCs. The permeation rate of DEA through excised mouse skins from hydrogel containing DEA-NLC (DEA-NLC-hydrogel) was 7.3 times higher than DEA-ointment. The skin deposition of DEA from DEA-NLC-hydrogel increased 3.8 folds compared to that from solution of DEA in hydrogel (DEA-hydrogel).
MATÉRIAUX
Numéro du produit
Marque
Description du produit
Sigma-Aldrich
Methanol solution, suitable for NMR (reference standard), 4% in methanol-d4 (99.8 atom % D), NMR tube size 3 mm × 8 in.