产品名称
抗-MFSD2A 兔抗, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
zebrafish ... mfsd2aa(492810)
Biochem/physiol Actions
包含2a（Mfsd2a）的主要促进子超家族结构域充当必需的omega-3脂肪酸二十二碳六烯酸的转运蛋白。它对于出生后大脑的生长在血脑屏障中至关重要。如果该基因存在遗传变异，则观察到从胚胎期到成年期的血脑屏障渗漏。MFSD2A基因突变导致小头畸形和心室肥大。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
含有2a（Mfsd2a）的主要促进子超家族结构域是钠依赖性溶血磷脂酰胆碱（LPC）转运蛋白。血脑屏障中微血管的内皮表达高水平的Mfsd2a。
Immunogen
MFSD2A抗体通过靶向人MFSD2A羧基末端附近的18个氨基酸多肽获得。
Other Notes
可以使用阻断肽SBP3500576阻断该抗体的作用。
Physical form
以含有0.02%叠氮化钠的PBS形式提供。
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-ZA, et al.
Nature, 507-511 (2014)
Inactivating Mutations in MFSD2A, Required for Omega-3 Fatty Acid Transport in Brain, Cause a Lethal Microcephaly Syndrome
Guemez-GA, et al.
Nature Genetics, 47(7), 809-809 (2015)
The lysolipid transporter Mfsd2a regulates lipogenesis in the developing brain
Chan JP, et al.
PLoS Biology, 16(8), e2006443-e2006443 (2018)
Takuro Iwao et al.
PloS one, 18(2), e0281946-e0281946 (2023-02-17)
Nutrients are actively taken up by the brain via various transporters at the blood-brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To
Long N Nguyen et al.
Nature, 509(7501), 503-506 (2014-05-16)
Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is essential for normal brain growth and cognitive function. Consistent with its importance in the brain, DHA is highly enriched in brain phospholipids. Despite being an abundant fatty acid in brain
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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