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Merck

SAB4503499

Anti-Cyclin A antibody produced in rabbit

affinity isolated antibody

别名:

Cyclin A1, cyclin A1

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.43
MDL number:
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产品名称

Anti-Cyclin A antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 52 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... CCNA1(8900)

Application

Anti-Cyclin A antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

CCNA1 (cyclin A1) controls cell apoptosis. Cyclin A2 is required for DNA replication and proliferation in somatic cells. CCNA1 plays an important role in head and neck carcinoma and cervical and nasopharyngeal cancers.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Anti-Cyclin A Antibody detects endogenous levels of total Cyclin A protein.
CCNA1 (cyclin A1) is a member of the highly conserved cyclin family. There are two A-type cyclins, namely cyclin A1 and cyclin A2. Cyclin A1 is expressed at high levels in testis and expressed at low levels in most other tissues. This gene is mapped to human chromosome 13q13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Cyclin A.

Immunogen Range: 221-270

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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存储类别

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16.
Weiss D, et al.
BMC Cancer, 12(1), 259-259 (2012)
Depletion of HOXA5 inhibits the osteogenic differentiation and proliferation potential of stem cells from the apical papilla.
Li W, et al.
Cell Biology International, 42(1), 45-52 (2018)
Correlation of CCNA1 promoter methylation with malignant tumors: a meta-analysis introduction.
Yang B, et al.
BioMed Research International, 2015, 134027-134027 (2015)
Wenzhi Li et al.
Cell biology international, 42(1), 45-52 (2017-08-24)
Mesenchymal stem cells (MSCs) are a prospective cell source for tissue regeneration due to their self-renewal abilities and potential to differentiate into different cell lineages, but the molecular mechanisms of the directed differentiation and proliferation are still unknown. Recently, multiple
PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression
Qu X, et al.
Journal of Translational Medicine, 13(1), 301-301 (2015)

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