B5016

Bepridil hydrochloride

Name: Bepridil hydrochloride
Brand: SIGMA

calcium channel blocker, powder

Synonym(s):

1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₄N₂O · HCl

CAS Number:

68099-86-5

Molecular Weight:

403.00

MDL number:

MFCD00065498

UNSPSC Code:

12352202

PubChem Substance ID:

24277824

NACRES:

NA.77

Key Documents

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Product Name

Bepridil hydrochloride, powder

form

powder

Quality Level

100

originator

Johnson & Johnson

SMILES string

Cl.CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3

InChI

1S/C24H34N2O.ClH/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22;/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;1H

InChI key

JXBBWYGMTNAYNM-UHFFFAOYSA-N

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

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This Item	B2417	P4670	SML1261
Sigma-Aldrich B5016 Bepridil hydrochloride	Sigma-Aldrich B2417 Benzamil hydrochloride hydrate	Sigma-Aldrich P4670 Propafenone hydrochloride	Sigma-Aldrich SML1261 Asimadoline hydrochloride
form powder	form solid	form powder	form powder
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
originator Johnson & Johnson	originator -	originator Abbott	originator -
Gene Information human ... CACNA1A(773), CACNA1B(774), CACNA1C(775), CACNA1D(776), CACNA1E(777), CACNA1F(778), CACNA1G(8913), CACNA1H(8912), CACNA1I(8911), CACNA1S(779), CACNA2D1(781), CACNA2D2(9254), CACNA2D3(55799), CACNA2D4(93589), CACNB1(782), CACNB2(783), CACNB3(784), CACNB4(785), CACNG1(786), CACNG2(10369), CACNG3(10368), CACNG4(27092), CACNG5(27091), CACNG6(59285), CACNG7(59284), CACNG8(59283)	Gene Information human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340) mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278) rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)	Gene Information human ... ABCB1(5243), ADRB1(153), ADRB2(154), ADRB3(155), CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)	Gene Information -

Biochem/physiol Actions

Non-selective calcium channel blocker and class IV antiarrhythmic agent; inhibits Na⁺-Ca²⁺ exchange; inhibits growth of brain tumor cells in vitro.

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.

Chikako Shimizu et al.

Biological & pharmaceutical bulletin, 41(7), 1049-1061 (2018-05-18)

Ethanol (EtOH) dosage, frequency, and paired associative learning affect the risk of alcoholism. Recently, Spanagel et al. reported that acamprosate calcium (Acam Ca) prescribed for alcoholism exerts an anti-relapse effect via Ca. Ca is contained in foods, sometimes consumed with

In vitro and experimental therapeutic studies of the calcium channel blocker bepridil: detection of viable Leishmania (L.) chagasi by real-time PCR.

Juliana Q Reimão et al.

Experimental parasitology, 128(2), 111-115 (2011-03-01)

The need for novel and efficacious drugs against neglected parasitic diseases, such as Leishmaniasis and American Trypanosomiasis, is certainly apparent. In this work, we evaluated the in vitro potential of the calcium channel blocker bepridil against Leishmania spp. and Trypanosoma

Intracellular and extracellular pH and Ca are bound to control mitosis in the early sea urchin embryo via ERK and MPF activities.

Brigitte Ciapa et al.

PloS one, 8(6), e66113-e66113 (2013-06-21)

Studies aiming to predict the impact on marine life of ocean acidification and of altered salinity have shown altered development in various species including sea urchins. We have analyzed how external Na, Ca, pH and bicarbonate control the first mitotic

Bepridil blunts the shortening of action potential duration caused by metabolic inhibition via blockade of ATP-sensitive K(+) channels and Na(+)-activated K(+) channels.

Y Li et al.

The Journal of pharmacology and experimental therapeutics, 291(2), 562-568 (1999-10-19)

The effects of bepridil, a potent antiarrhythmic drug, on the activity of ATP-sensitive K(+) (K(ATP)) channels and Na(+)-activated K(+) (K(Na)) channels were examined in isolated patches from guinea pig ventricular myocytes. In inside-out membrane patches, K(ATP) channel currents were recorded

Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension.

Lassina Badolo et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 40(4), 282-288 (2010-04-13)

Drug-drug interactions involving hepatic drug transporters may have clinical consequences and jeopardize development of promising drug candidates. Organic anion transporting polypeptides (OATP/Oatp) and the organic cation transporters (OCT/Oct) are among the most important transporters involved in xenobiotic uptake in the

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