1.37037

Guanidinium chloride

EMPROVE^® EXPERT, NF

• Sinonim: Guanidine hydrochloride, Guanidinum hydrochloride, Carbamimidoylazanium chloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride
• Rumus Linier: NH₂C(=NH)NH₂ · HCl
• CAS Number: 50-01-1
• Berat Molekul: 95.53
• Beilstein/REAXYS Number: 3591990
• MDL number: MFCD00013026
• UNSPSC Code: 12352107
• EC Index Number: 200-002-3

Properti

• agency: NF
• Quality Level: 500
• product line: EMPROVE^® EXPERT
• potency: 655.3-907.1 mg/kg LD₅₀, oral (Rat); >2000 mg/kg LD₅₀, skin (Rabbit)
• feature: RNase and DNase free
• pH: 4.5-5.5 (20 °C, 100 g/L in H₂O)
• mp: 180-185 °C (lit.); 188 °C
• solubility: 2150 g/L
• density: 1.3 g/cm³ (lit.)
• bulk density: 550‑620 kg/m³
• storage temp.: 15-25°C
• SMILES string: Cl[H].NC(N)=N
• InChI: 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H
• InChI key: PJJJBBJSCAKJQF-UHFFFAOYSA-N

Deskripsi

General description

Finding the right chemical that matches your pharma and biopharma manufacturing needs as well as regulatory demands can be a complicated challenge. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for pharma and biopharma manufacturing withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Our SAFC^® portfolio of high-quality products for biopharmaceutical processing withstands strict quality control procedures and is produced according to MQ-500 requirements as defined by the M-Clarity program.

M-Clarity Program

As part of our EMPROVE^® Program, our raw materials are offered with EMPROVE^® Dossiers which provide comprehensive, up-to-date documentation to help you navigate regulatory challenges, manage risks, and improve your manufacturing processes.

Our comprehensive portfolio of downstream process chemicals not only provides biopharmaceutical manufacturers with high-quality raw materials for production of classical and novel therapies, but also helps them get to market faster and simplify regulatory challenges. Ranging from non-GMP grades for low-risk application, to IPEC-PQG GMP for higher-risk applications, we have products covering all your manufacturing needs.

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Other Notes

Due to its low microbial and endotoxin limits, Guanidinium chloride Emprove^® Expert is suitable for biopharma manufacturing needs.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informasi Keselamatan

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H332 - H315 - H319
• pcodes: P261 - P264 - P301 + P312 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Kelas Penyimpanan: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable