216100-M

Carboplatin

An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

• Sinonim: Carboplatin, cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II), JM-8, Paraplatin
• Rumus Empiris (Notasi Bukit): C₆H₁₂N₂O₄Pt
• CAS Number: 41575-94-4
• Berat Molekul: 371.25
• MDL number: MFCD00070464
• UNSPSC Code: 12352200
• NACRES: NA.77

Properti

• Quality Level: 100
• description: Merck USA index - 14, 1822
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: white
• solubility: water with 5% glucose: 10 mg/mL
• storage temp.: 10-30°C
• SMILES string: [Pt]1OC(=O)C2(CCC2)C(=O)O1.[N+H4].[N+H4]
• InChI: 1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2
• InChI key: OLESAACUTLOWQZ-UHFFFAOYSA-N

Deskripsi

General description

An analog of Cisplatin (Cat. No. 232120 ) with reduced nephrotoxicity. Displays potent antitumor activity.


Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

An analog of cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.



Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Primary Target
Potent antitumor activity

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hall, M.D., et al. 2014. Cancer Res. In press.
Smith, I.E., et al. 1985. Cancer Treat. Rep. 69, 43.
Harland, S.J., et al. 1984. Cancer Res. 44, 1693.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Informasi Keselamatan

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H317,H334,H340,H360
• pcodes: P202 - P261 - P280 - P301 + P312 - P302 + P352 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1
• Kelas Penyimpanan: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable