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77151

Pepsin from porcine gastric mucosa

powder, slightly beige, 1200-2400 U/mg

Synonym(s):

Pepsin A, Pepsin from hog stomach

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About This Item

CAS Number:
9001-75-6
UNSPSC Code:
12352204
eCl@ss:
42010127
EC Number:
232-629-3
NACRES:
NA.54
MDL number:
MFCD00081840
EC Number:
3.4.23.1 (BRENDA, IUBMB)

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Product Name

Pepsin from porcine gastric mucosa, powder, slightly beige, 1200-2400 U/mg

form

powder

specific activity

1200-2400 U/mg

mol wt

35 kDa

color

slightly beige

UniProt accession no.

P00791

storage temp.

2-8°C

Gene Information

pig ... LOC396892(396892)

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This Item
77160P7125P6887
Pepsin from porcine gastric mucosa powder, slightly beige, 1200-2400 U/mg

Sigma-Aldrich

77151

Pepsin from porcine gastric mucosa

Pepsin from porcine gastric mucosa powder, slightly beige, ≥500 U/mg

Sigma-Aldrich

77160

Pepsin from porcine gastric mucosa

Pepsin from porcine gastric mucosa powder, ≥400 units/mg protein

Sigma-Aldrich

P7125

Pepsin from porcine gastric mucosa

Pepsin from porcine gastric mucosa lyophilized powder, ≥3,200 units/mg protein

Sigma-Aldrich

P6887

Pepsin from porcine gastric mucosa

Gene Information

pig ... LOC396892(396892)

Gene Information

pig ... LOC396892(396892)

Gene Information

pig ... LOC396892(396892)

Gene Information

pig ... LOC396892(396892)

specific activity

1200-2400 U/mg

specific activity

≥500 U/mg

specific activity

≥400 units/mg protein

specific activity

≥3,200 units/mg protein

form

powder

form

powder

form

powder

form

lyophilized powder

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

UniProt accession no.

P00791

UniProt accession no.

P00791

UniProt accession no.

P00791

UniProt accession no.

P00791

mol wt

35 kDa

mol wt

35 kDa

mol wt

35 kDa

mol wt

35 kDa

Analysis Note

Optimum pH is 2-4. Active in 4 M urea and 3 M guanidine HCl. Stable at 60 °C. Pepsin is irreversibly inactivated at pH 8.0 - 8.5.

Application

Pepsin cleavage can be used to produce F(ab′)2 fragments of antibodies. pepsin at www.sigma-aldrich.com/enzymeexplorer.

Biochem/physiol Actions

Preferential cleavage: hydrophobic and aromatic residues in P1 and P1′ postitions. Cleaves Phe-Val, Gln-His, Glu-Ala, Ala-Leu, Leu-Tyr, Tyr-Leu, Gly-Phe, Phe-Phe and Phe-Tyr bonds in the β chain of insulin

Disclaimer

Sales restrictions may apply.

Other Notes

1 U corresponds to the amount of enzyme which increases the absorbance at 280 nm by 0.001 per minute at pH 2.0 and 37°C (Hemoglobin, Cat.No. 51290, as substrate) 15′000 absorbance-U as described above are equivalent to ∼1 Bergmeyer-U. 1 Bergmeyer-U is the amount of enzyme which hydrolyzes 1 μmol Acetyl-L-phenyl-3,5-diiodo-L-tyrosine at pH 2.0 and 37°C

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM3416
BCCL0498
BCCH3958
BCCD3890
BCBZ8624

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Gastric proteinases--structure, function, evolution and mechanism of action.
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