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85605

Spermine tetrahydrochloride

Name: Spermine tetrahydrochloride
Brand: SIGMA

BioUltra, Molecular Biology, ≥99.5% (AT)

Sinonimo/i:

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₀H₂₆N₄ · 4HCl

Numero CAS:

306-67-2

Peso molecolare:

348.18

UNSPSC Code:

12352116

NACRES:

NA.26

PubChem Substance ID:

57653056

EC Number:

206-189-8

Beilstein/REAXYS Number:

3911771

MDL number:

MFCD00012914

Assay:

≥99.5% (AT)

Form:

powder

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Servizio Tecnico

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Proprietà

grade

Molecular Biology

Quality Segment

300

product line

BioUltra

assay

≥99.5% (AT)

form

powder

impurities

DNases, none detected, RNases, none detected, insoluble matter, passes filter test, phosphatases, none detected, proteases, none detected

pH

4.5-7.0 (25 °C, 1 M in H₂O)

mp

310-311 °C (dec.) (lit.)

solubility

H₂O: 1 m at 20 °C, clear, colorless to almost colorless

anion traces

sulfate (SO₄^2-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg, As: ≤0.1 mg/kg, Ba: ≤5 mg/kg, Bi: ≤5 mg/kg, Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤50 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Sr: ≤5 mg/kg, Zn: ≤5 mg/kg

λ

1 M in H₂O

UV absorption

λ: 260 nm A_max: 0.2, λ: 280 nm A_max: 0.15

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

Descrizione

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Other Notes

Spermine precipitation of DNA.

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Questo articolo	S1141	85610	5677
Sigma-Aldrich 85605 Spermine tetrahydrochloride	Sigma-Aldrich S1141 Spermine tetrahydrochloride	Sigma-Aldrich 85610 Spermine tetrahydrochloride	Sigma-Aldrich 5677 Spermine, Tetrahydrochloride
description BioUltra, Molecular Biology, ≥99.5% (AT)	description BioReagent, Molecular Biology	description ≥99.0% (AT), powder or crystals	description -
form powder	form solid	form powder or crystals	form solid
assay ≥99.5% (AT)	assay -	assay ≥99.0% (AT)	assay ≥99% (titration)
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 100
solubility H₂O: 1 m at 20 °C, clear, colorless to almost colorless	solubility H₂O: soluble 100 mg/mL, clear, colorless to light yellow	solubility H₂O: 0.1 g/mL, clear	solubility water: 20 mg/mL
impurities insoluble matter, passes filter test, RNases, none detected, phosphatases, none detected, DNases, none detected, proteases, none detected	impurities -	impurities -	impurities -
cation traces Mn: ≤5 mg/kg, Li: ≤5 mg/kg, As: ≤0.1 mg/kg, Co: ≤5 mg/kg, Zn: ≤5 mg/kg, Ni: ≤5 mg/kg, Bi: ≤5 mg/kg, Pb: ≤5 mg/kg, Al: ≤5 mg/kg, Mo: ≤5 mg/kg, Ca: ≤10 mg/kg, Ba: ≤5 mg/kg, K: ≤50 mg/kg, Mg: ≤5 mg/kg, Sr: ≤5 mg/kg, Fe: ≤5 mg/kg, Cu: ≤5 mg/kg, Cr: ≤5 mg/kg, Na: ≤50 mg/kg, Cd: ≤5 mg/kg	cation traces -	cation traces -	cation traces -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Classe di stoccaggio

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c