O0877
Oxolinic acid
quinolone antibiotic
Sinonimo/i:
5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 5 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 103,00 € | |
| 25 g | Per informazioni sulla disponibilità, contatta il Servizio Clienti. | 394,00 € |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C13H11NO5
Numero CAS:
Peso molecolare:
261.23
UNSPSC Code:
51282935
NACRES:
NA.85
PubChem Substance ID:
EC Number:
238-750-8
Beilstein/REAXYS Number:
620635
MDL number:
103,00 €
Per informazioni sulla disponibilità, contatta il Servizio Clienti.
Servizio Tecnico
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Permettici di aiutartiQuality Level
antibiotic activity spectrum
Gram-negative bacteria
mode of action
DNA synthesis | interferes, enzyme | inhibits
storage temp.
2-8°C
SMILES string
CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
InChI
1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
InChI key
KYGZCKSPAKDVKC-UHFFFAOYSA-N
General description
Chemical structure: quinolone
Application
Oxolinic acid is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia coli and Salmonella enterica. Oxolinic acid is added to culture medium for the isolation of Gardnerella vaginalis[1].
Biochem/physiol Actions
Oxolinic acid is a quinolone antibiotic. It is a DNA-gyrase (topoisomerase II) inhibitor used for studies on DNA winding and coiling and acts as a dopamine reuptake inhibitor for studies on dopaminergic neurotransmission processes.
Other Notes
5g,25g
Keep container tightly closed in a dry and well-ventilated place.
1 of 1
Questo articolo | |||
|---|---|---|---|
| mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - | mode of action DNA synthesis | interferes, enzyme | inhibits | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - | antibiotic activity spectrum Gram-negative bacteria | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe di stoccaggio
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Contenuto correlato
Product Information Sheet
J Garcia de Mateos-Verchere et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 8(4), 255-259 (1999-02-03)
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in locomotor activity. This stimulation culminated at the 32 mg/kg dose and became smaller for higher doses (64-128 mg/kg). When opposed to increasing doses (50-100-200 microg/kg
J S Thompson
Journal of clinical microbiology, 21(5), 843-843 (1985-05-01)
Colistin-oxolinic acid medium is proposed as a selective isolation medium for Gardnerella vaginalis. The medium is effective in inhibiting staphylococci and gram-negative bacteria while allowing growth of G. vaginalis.
Xiuhong Wang et al.
The Journal of antimicrobial chemotherapy, 65(3), 520-524 (2010-01-14)
Quinolone-mediated death of Escherichia coli has been proposed to occur by two pathways. One is blocked by inhibitors of protein synthesis; the other is not. It is currently unknown how these two pathways fit with the recent observation that hydroxyl
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| O0877-25G | 04061834212652 |
| O0877-5G | 04061835507078 |