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P186

PD 123,319 di(trifluoroacetate) salt hydrate

Name: PD 123,319 di(trifluoroacetate) salt hydrate
Brand: SIGMA

≥98% (HPLC), angiotensin II subtype-2 receptor antagonist, powder

Sinonimo/i:

S-(+)-1-[(4-(Dimethylamino)-3-methylphenyl)methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid di(trifluoroacetate) salt hydrate

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₃₁H₃₂N₄O₃ · 2C₂HF₃O₂ · xH₂O

Numero CAS:

136676-91-0

Peso molecolare:

736.66 (anhydrous basis)

UNSPSC Code:

12352202

PubChem Substance ID:

24898250

NACRES:

NA.32

MDL number:

MFCD11046022

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Nome del prodotto

PD 123,319 di(trifluoroacetate) salt hydrate, powder, ≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

H₂O: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C

InChI

1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1

InChI key

PTSUEYBWHKDYBS-FPCIESGBSA-N

Categorie correlate

Bioactive Small Molecules

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Questo articolo	P5749	F9932	SML2335
Sigma-Aldrich P186 PD 123,319 di(trifluoroacetate) salt hydrate	Sigma-Aldrich P5749 S-(+)-PD 123177 trifluoroacetate salt hydrate	Sigma-Aldrich F9932 FFN511 trifluoroacetate salt hydrate	Sigma-Aldrich SML2335 IACS-9571 trifluoroacetate salt
form powder	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility H₂O: 10 mg/mL, clear	solubility H₂O: >5 mg/mL	solubility DMSO: ≥20 mg/mL	solubility DMSO: 2 mg/mL, clear
storage condition desiccated	storage condition -	storage condition desiccated	storage condition -

Application

PD123,319 di (trifluoroacetate) salt hydrate has been used in following experimental studies:

To determine the effect of Angiotensin II (Ang II) on alveolar fluid clearance (AFC).
To study the effect of PD123319 on AngII-induced abdominal aortic aneurysms (AAAs).
To study its effect on Ang II-induced LRP1 overexpression and function in vascular smooth muscle cells (VSMCs) culture.

Biochem/physiol Actions

PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.

Disclaimer

Hygroscopic

pictograms

GHS07

signalword

Warning

hcodes

H315,H319,H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Numero articolo commerciale globale

SKU	GTIN
P186-10MG	04061834356998

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