- Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
Long-term potentiation is independent of the C-tail of the GluA1 AMPA receptor subunit.
eLife (2020-08-25)
Javier Díaz-Alonso, Wade Morishita, Salvatore Incontro, Jeffrey Simms, Julia Holtzman, Michael Gill, Lennart Mucke, Robert C Malenka, Roger A Nicoll
PMID32831170
ABSTRACT
We tested the proposal that the C-terminal domain (CTD) of the AMPAR subunit GluA1 is required for LTP. We found that a knock-in mouse lacking the CTD of GluA1 expresses normal LTP and spatial memory, assayed by the Morris water maze. Our results support a model in which LTP generates synaptic slots, which capture passively diffusing AMPARs.