- 2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
Bioorganic & medicinal chemistry letters (2003-09-03)
Yun He, Baogen Wu, Jun Yang, Dale Robinson, Lisa Risen, Ray Ranken, Lawrence Blyn, Suzie Sheng, Eric E Swayze
PMID12951103
ABSTRACT
A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.
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