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Asymmetric synthesis of (+)-cis-nemorensic acid from a chiral Diels-Alder adduct of 2,5-dimethylfuran.

Chemical communications (Cambridge, England) (2007-12-01)
Jae Yi Sim, Geum-Sook Hwang, Kyung Hwa Kim, Eun Mi Ko, Do Hyun Ryu
ABSTRACT

(+)-cis-Nemorensic acid was synthesized from a chiral Diels-Alder adduct prepared by a catalytic enantioselective Diels-Alder reaction with 2,5-dimethylfuran and 2,2,2-trifluoroethyl acrylate.

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Sigma-Aldrich
2,5-Dimethylfuran, 99%