Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking.

Synthesis and incorporation of a furan-modified adenosine building block for DNA interstrand crosslinking.

Chemical communications (Cambridge, England) (2011-02-03)

Anup M Jawalekar, Marieke Op de Beeck, Floris L van Delft, Annemieke Madder

ABSTRACT

2'-O-(3-(Furan-2-yl)propyl)adenosine was synthesized and evaluated for interstrand crosslink (ICL) formation in DNA duplexes. In situ oxidation of the furan moiety with NIS showed rapid crosslink formation to dA and dC, while dT and dG were inactive.

MATERIALI

Numero di prodotto

Marchio

Descrizione del prodotto

220051

Sigma-Aldrich

N-Iodosuccinimide, 95%