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Merck

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.

Nature neuroscience (2013-05-28)
Elizabeth M Bradshaw, Lori B Chibnik, Brendan T Keenan, Linda Ottoboni, Towfique Raj, Anna Tang, Laura L Rosenkrantz, Selina Imboywa, Michelle Lee, Alina Von Korff, Martha C Morris, Denis A Evans, Keith Johnson, Reisa A Sperling, Julie A Schneider, David A Bennett, Philip L De Jager
PMID23708142
ABSTRACT

In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young and older individuals. It was also associated with diminished internalization of amyloid-β 42 peptide, accumulation of neuritic amyloid pathology and fibrillar amyloid on in vivo imaging, and increased numbers of activated human microglia.

MATERIALI
Numero di prodotto
Marchio
Descrizione del prodotto
31390
Sigma-Aldrich
Destrano, Mr ~70,000
31389
Sigma-Aldrich
Destrano, Mr ~40,000
31392
Sigma-Aldrich
Destrano, Mr 450,000-650,000
31388
Sigma-Aldrich
Destrano, Mr ~6,000
D5376
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
D1662
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 35,000-45,000
D9260
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 9,000-11,000
D8821
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 60,000-76,000
09184
Sigma-Aldrich
Destrano, Mr ~100,000
00271
Supelco
Dextran, analytical standard, 25,000
D4876
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 150,000
31425
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 670,000
00269
Supelco
Dextran, analytical standard, 5,000
31430
Supelco
Dextran, analytical standard, suitable for gel permeation chromatography (GPC), Set Mp 1,000-400,000
00896
Supelco
Dextran, analytical standard, 670,000
00893
Supelco
Dextran, analytical standard, 150,000
00268
Supelco
Dextran, analytical standard, 1,000
00894
Supelco
Dextran, analytical standard, 270,000
31398
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, Mr ~200,000
00270
Supelco
Dextran, analytical standard, 12,000
31387
Sigma-Aldrich
Destrano, Mr 15,000-25,000
D8802
Sigma-Aldrich
Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
31397
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, Mr ~60,000
00895
Supelco
Dextran, analytical standard, 410,000
31394
Sigma-Aldrich
Dextran, enzymatic synth.
00891
Supelco
Dextran, analytical standard, 50,000
31417
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, suitable for gel permeation chromatography (GPC), Mw 5,000
00892
Supelco
Dextran, analytical standard, 80,000
31416
Supelco
Dextran from Leuconostoc mesenteroides, analytical standard, Mw 1,000
D3759
Sigma-Aldrich
Dextran from Leuconostoc mesenteroides, average mol wt 48,000-90,000