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Merck
  • Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.

Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery.

Carbohydrate polymers (2013-04-03)
Santanu Kaity, Jinu Isaac, Animesh Ghosh
PMID23544563
ABSTRACT

A novel interpenetrating polymer network (IPN) microspheres of locust bean gum (LBG) and poly (vinyl alcohol) (PVA) was developed for oral controlled release of buflomedil hydrochloride (BH) by emulsion crosslinking method using glutaraldehyde as crosslinker. The effects of gum-polymer ratio, concentration of crosslinker and internal phase viscosity were evaluated thoroughly. Drug entrapment efficiency, particle size distribution, swelling property and in vitro release characteristics with kinetic modelling of microspheres were evaluated. The microspheres were characterised by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), solid state C(13) NMR, X-ray diffraction study (XRD) and differential scanning colorimetry (DSC). The microspheres showed control release property without showing any incompatibility in IPN device. Hence, IPN microspheres of LBG and PVA can be used as a potential carrier for controlled oral delivery of highly water soluble drugs like BH.

MATERIALI
Numero di prodotto
Marchio
Descrizione del prodotto
341584
Sigma-Aldrich
Alcol poli(vinilico), Mw 89,000-98,000, 99+% hydrolyzed
360627
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Alcol poli(vinilico), Mw 8,000-10,000, 80% hydrolyzed
G5882
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Glutaraldeide, Grade I, 25% in H2O, specially purified for use as an electron microscopy fixative
363065
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Alcol poli(vinilico), Mw 150,000 (average), 99+% hydrolyzed
G6257
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Glutaraldeide, Grade II, 25% in H2O
340855
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Glutaraldeide, 50 wt. % in H2O
P8136
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Alcol poli(vinilico), 87-90% hydrolyzed, average mol wt 30,000-70,000
363170
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Alcol poli(vinilico), Mw 13,000-23,000, 87-89% hydrolyzed
363146
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Alcol poli(vinilico), Mw 85,000-124,000, 99+% hydrolyzed
363138
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Alcol poli(vinilico), Mw 31,000-50,000, 98-99% hydrolyzed
81381
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Alcol poli(vinilico), Mw ~31,000
363081
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Alcol poli(vinilico), average Mw 85,000-124,000, 87-89% hydrolyzed
P1763
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Alcol poli(vinilico), Fully hydrolyzed
363073
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Alcol poli(vinilico), average Mw 31,000-50,000, 87-89% hydrolyzed
G7651
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Glutaraldeide, Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
363103
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Alcol poli(vinilico), average Mw 146,000-186,000, 87-89% hydrolyzed
348406
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Alcol poli(vinilico), average Mw 13,000-23,000, 98% hydrolyzed
81365
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Alcol poli(vinilico), Mw ~130,000
G7776
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Glutaraldeide, Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
81383
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Alcol poli(vinilico), Mw ~67,000
563900
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Alcol poli(vinilico), average Mw 130,000, 99+% hydrolyzed
49629
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Glutaraldeide, technical, ~50% in H2O (5.6 M)
G7526
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Glutaraldeide, Grade I, 8% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use
G6403
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Glutaraldeide, 50% in H2O, suitable for photographic applications
81382
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Alcol poli(vinilico), Mw ~27,000
10851
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Alcol poli(vinilico), Mw ~195,000
324590
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Alcol poli(vinilico), average Mw ~205,000 g/mol
10849
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Alcol poli(vinilico), Mw ~145,000
11773
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Alcol poli(vinilico), Mw ~125,000
10852
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Alcol poli(vinilico), Mw ~61,000