Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.

Phenotypic and genotypic characterization of acyclovir-resistant corneal HSV-1 isolates from immunocompetent patients with recurrent herpetic keratitis.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (2013-06-05)

Sonia Burrel, David Boutolleau, Georges Azar, Serge Doan, Claire Deback, Isabelle Cochereau, Henri Agut, Eric E Gabison

ABSTRACT

Herpes simplex virus type 1 (HSV-1) is a leading cause of corneal blindness. Acyclovir (ACV) constitutes the standard treatment of HSV infections including herpetic keratitis (HK). HSV resistance to ACV is mainly described in immunocompromised patients. We describe two cases of ACV-resistant corneal HSV-1 in immunocompetent individuals with recurrent HK.

MATERIALI

Numero di prodotto

Marchio

Descrizione del prodotto

PHR1254

Supelco

Acyclovir, Pharmaceutical Secondary Standard; Certified Reference Material

Prezzi e disponibilità al momento non sono disponibili

A4669

Sigma-Aldrich

Acycloguanosine, ≥99% (HPLC), powder

Prezzi e disponibilità al momento non sono disponibili

A0220000

Aciclovir, European Pharmacopoeia (EP) Reference Standard

Prezzi e disponibilità al momento non sono disponibili