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Asymmetric synthesis of functionalized diarylmethanols catalyzed by a new gamma-amino thiol.

The Journal of organic chemistry (2006-01-18)
Ping-Yu Wu, Hsyueh-Liang Wu, Biing-Jiun Uang
ABSTRACT

[reaction: see text] A mild asymmetric arylation of aromatic aldehydes catalyzed by gamma-amino thiol 5 gave the corresponding diarylmethanols with 95 to >99.5% ee.

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Sigma-Aldrich
2-Bromoethyl ether, technical grade, 90%