Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors.

Bioorganic & medicinal chemistry letters (2007-09-22)

Sébastien Guery, Philipp Floersheim, Klemens Kaupmann, Wolfgang Froestl

ABSTRACT

The optimization of GS39783 into potent, selective, and safe positive allosteric modulators of GABA(B) receptors is presented.

MATERIALI

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Marchio

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Sigma-Aldrich

5-Bromo-2,4-dichloropyrimidine, 97%

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