- The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
The transcription factor mohawk homeobox regulates homeostasis of the periodontal ligament.
Development (Cambridge, England) (2016-12-21)
Naoki Koda, Tempei Sato, Masahiro Shinohara, Shizuko Ichinose, Yoshiaki Ito, Ryo Nakamichi, Tomohiro Kayama, Kensuke Kataoka, Hidetsugu Suzuki, Keiji Moriyama, Hiroshi Asahara
PMID27993989
ABSTRACT
The periodontal ligament (PDL), which connects the teeth to the alveolar bone, is essential for periodontal tissue homeostasis. Although the significance of the PDL is recognized, molecular mechanisms underlying PDL function are not well known. We report that mohawk homeobox (Mkx), a tendon-specific transcription factor, regulates PDL homeostasis by preventing its degeneration. Mkx is expressed in the mouse PDL at the age of 10 weeks and expression remained at similar levels at 12 months. In Mkx
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Sigma-Aldrich
Anticorpo monoclonale ANTI-FLAG® M2, 1 mg/mL, clone M2, affinity isolated antibody, buffered aqueous solution (50% glycerol, 10 mM sodium phosphate, and 150 mM NaCl, pH 7.4)