- Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
Synergy of a hepatitis C virus (HCV) NS4A antagonist in combination with HCV protease and polymerase inhibitors.
Antimicrobial agents and chemotherapy (2008-03-12)
David L Wyles, Kelly A Kaihara, Robert T Schooley
PMID18332167
ABSTRACT
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.
MATERIALI
Numero di prodotto
Marchio
Descrizione del prodotto
Sigma-Aldrich
Interferon-αA/D human, ≥95%, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture