All Photos(1)

PHR1036

Supelco

Pyridoxine hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Adermine hydrochloride, Vitamin B6 hydrochloride, PN HCl, 3-Hydroxy-4,5-bis (hydroxymethyl)-2-picoline hydrochloride, Pyridoxol hydrochloride
Empirical Formula (Hill Notation):
C8H11NO3 · HCl
CAS Number:
Molecular Weight:
205.64
Beilstein:
3632435
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

214-215 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 458
traceable to PhEur P4100000
traceable to USP 1587001

SMILES string

Cl[H].Cc1ncc(CO)c(CO)c1O

InChI

1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

InChI key

ZUFQODAHGAHPFQ-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

General description

Pyridoxine hydrochloride is a water soluble vitamin, widely used for the prevention of peripheral neuropathy and central nervous system effects associated with therapy involving isoniazid. It is highly required for the formation of hemoglobin and is also mainly involved in carbohydrate, fat and amino acid metabolism.

Application

Pyridoxine hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB3720 in the slot below. This is an example certificate only and may not be the lot that you receive.

pictograms

Corrosion

signalword

Danger

hcodes

Hazard Classifications

Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 1

Certificate of Analysis

Certificate of Origin

Development and validation of RP-HPLC method for simultaneous determination of pyridoxine hydrochloride, isoniazid, pyrazinamide and rifampicin in pharmaceutical formulation
Dhal KS and Sharma R
Chem. Anal. (Warsaw), 54(6), 1487-1487 (2009)
Simultaneous derivative spectrophotometric analysis of doxylamine succinate, pyridoxine hydrochloride and folic acid in combined dosage forms
Pathak A and Rajput JS
Indian Journal of Pharmaceutical Sciences, 70(4), 513-513 (2008)
Manfred Eggersdorfer et al.
Angewandte Chemie (International ed. in English), 51(52), 12960-12990 (2012-12-05)
The discovery of vitamins as essential factors in the diet was a scientific breakthrough that changed the world. Diseases such as scurvy, rickets, beriberi, and pellagra were recognized to be curable with an adequate diet. These diseases had been prevalent...
Clara D M van Karnebeek et al.
Molecular genetics and metabolism, 107(3), 335-344 (2012-10-02)
To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency. In this observational study, seven...
Sonia Fargue et al.
Biochimica et biophysica acta, 1832(10), 1776-1783 (2013-04-20)
Primary hyperoxaluria type 1 (PH1) is a rare hereditary calcium oxalate kidney stone disease caused by a deficiency of the liver-specific pyridoxal-phosphate-dependent peroxisomal enzyme alanine:glyoxylate aminotransferase (AGT). About one third of patients are responsive to pharmacological doses of pyridoxine (vitamin...

Protocols

LC/MS/MS Analysis of Vitamins B1 and B6 on Ascentis® Express OH5

Separation of Pyridoxine Hydrochloride (B6), analytical standard; Thiamine Hydrochloride (B1), analytical standard

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service