Porous silicon advances in drug delivery and immunotherapy.

Porous silicon advances in drug delivery and immunotherapy.

Current opinion in pharmacology (2013-07-13)

David J Savage, Xuewu Liu, Steven A Curley, Mauro Ferrari, Rita E Serda

要旨

Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Recent findings support superior therapeutic efficacy of the multistage vector approach over single particle drug delivery systems in mouse models of ovarian and breast cancer. With respect to vaccine development, multivalent presentation of pathogen-associated molecular patterns on the particle surface creates powerful platforms for immunotherapy, with the porous matrix able to carry both antigens and immune modulators.

材料

製品番号

ブランド

製品内容

215619

Sigma-Aldrich

ケイ素, powder, −325 mesh, 99% trace metals basis

646687

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

633097

Sigma-Aldrich

ケイ素, nanopowder, <100 nm particle size (TEM), ≥98% trace metals basis

647101

Sigma-Aldrich

ケイ素, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 2 in. × 0.5 mm

647764

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

647675

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.5 mm

647535

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

647799

Sigma-Aldrich

ケイ素, wafer (single side polished), contains phosphorus as dopant, <111>, N-type, diam. × thickness 2 in. × 0.5 mm

343250

Sigma-Aldrich

ケイ素, pieces, 99.95% trace metals basis

647705

Sigma-Aldrich

ケイ素, wafer, <111>, P-type, contains boron as dopant, diam. × thickness 2 in. × 0.3 mm

647780

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 2 in. × 0.5 mm

647802

Sigma-Aldrich

ケイ素, wafer (single side polished), <100>, N-type, contains phosphorus as dopant, diam. × thickness 3 in. × 0.5 mm

647772

Sigma-Aldrich

ケイ素, wafer (single side polished), <111>, P-type, contains boron as dopant, diam. × thickness 3 in. × 0.5 mm

647543

Sigma-Aldrich

ケイ素, wafer (single side polished), <111>, N-type, contains no dopant, diam. × thickness 3 in. × 0.5 mm

GF73529051

ケイ素, sheet, 52x52mm, thickness 1.0mm, polycrystalline, 99.999%

GF46268433

ケイ素, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF91141792

ケイ素, sheet, 10x10mm, thickness 0.5mm, single crystal, -100, 100%

GF71817543

ケイ素, sheet, 10x10mm, thickness 0.6mm, single crystal, -100, 100%

GF10907377

ケイ素, rod, 80mm, diameter 20mm, single crystal, -100, 99.999%

GF85621923

ケイ素, sheet, 40x40mm, thickness 3.0mm, single crystal, p-type, 100%

GF70438518

ケイ素, rod, 40mm, diameter 20mm, single crystal, -100, 99.999%

GF72027266

ケイ素, disks, 13mm, thickness 0.38mm, single crystal, 100%

GF05482852

ケイ素, rod, 50mm, diameter 2.0mm, crystalline, 100%

GF20311254

ケイ素, sheet, 25x25mm, thickness 1.0mm, polycrystalline, 99.999%

GF28448691

ケイ素, rod, 50mm, diameter 5mm, single crystal, -100, 99.999%

GF04814951

ケイ素, rod, 100mm, diameter 25mm, crystalline, 100%

GF41762493

ケイ素, sheet, 25x25mm, thickness 1.0mm, single crystal, -100, 100%

GF16286227

ケイ素, disks, 15.9mm, thickness 0.38mm, single crystal, n-type, 100%

GF40945754

ケイ素, rod, 50mm, diameter 5mm, single crystal, -111, 99.999%

GF43555664

ケイ素, rod, 25mm, diameter 3.15mm, single crystal - random orientation, 100%