04-804

Anti-NFAT1 Antibody, clone 8G4.2

clone 8G4.2, Upstate^®, from mouse

• 동의어(들): Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-Atp, T-cell transcription factor NFAT1
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified antibody
• 항체 생산 유형: primary antibodies
• 클론: 8G4.2, monoclonal
• 종 반응성: rat, mouse, human
• 제조업체/상표: Upstate^®
• 기술: immunofluorescence: suitable; western blot: suitable
• 동형: IgMκ
• NCBI 수납 번호: NP_001129493.1
• UniProt 수납 번호: Q13469
• 배송 상태: wet ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... NFATC2(4773)

설명

일반 설명

120-140 kDa

NFAT (Nuclear Factor of Activated T-cells) is a family of transcription factors that are located in the cytoplasm in their inactive state. NFAT translocates to the nucleus upon stimulation of the T-cell receptor where it plays a key role in gene expression in immune response. NFAT is dephosphorylated and activated by the phosphatase PP2B/Calcineurin. This results in its nuclear localization and transcriptional activity. For NFAT1 (NFATC2, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), calcineurin is known to target the region between residues 114-126. Mutations in this region of NFAT1 result in its inability to de-phosphorylate and subsequent nuclear translocation. Upon activation, NFAT mediates the transcriptional induction of cytokines and other immuno-regulatory genes during immune responses, and is expressed in T-cells, B-cells, mast cells and NK cells.

면역원

Epitope: N-term

GST-fusion protein corresponding to amino acids 1-297 of human NFAT1.

애플리케이션

Research Category
Signaling

Research Sub Category
Transcription Factors

This Anti-NFAT1 Antibody, clone 8G4.2 is validated for use in WB, IF for the detection of NFAT1.

생화학적/생리학적 작용

Detects NFAT1.

Other species have not been tested.

물리적 형태

Format: Purified

Purified mouse monoclonal in PBS with 0.05% NaN3.

제조 메모

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

분석 메모

Routinely evaluated by Western Blot

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable