06-600

Anti-NR2B Antibody

Upstate^®, from rabbit

• 동의어(들): N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 2B, N-methyl-D-aspartate receptor subunit 3, glutamate receptor subunit epsilon-2, glutamate receptor, ionotropic, N-methyl D-aspartate 2B
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 종 반응성: mouse, rat (based on 100% sequence homology)
• 종 반응성(상동성에 의해 예측): monkey (based on 100% sequence homology), canine (based on 100% sequence homology), bovine (based on 100% sequence homology), human (based on 100% sequence homology), chimpanzee (based on 100% sequence homology)
• 제조업체/상표: Upstate^®
• 기술: western blot: suitable
• 동형: IgG
• NCBI 수납 번호: NM_008171
• UniProt 수납 번호: Q13224
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: bovine ... Grin2B(537804) ; chimpanzee ... Grin2B(473373) ; dog ... Grin2B(494009) ; human ... GRIN2B(2904) ; mouse ... Grin2B(14812) ; rat ... Grin2B(24410) ; rhesus monkey ... Grin2B(698571)

설명

일반 설명

Glutamate receptor ionotropic, NMDA 2B (UniProt: Q01097; also known as GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B) is encoded by the Grin2b gene (Gene ID: 14812) in mouse. NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B or NR2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer′s disease, epilepsy and ischemic neuronal cell death.

Target molecular weight ~165 kDa observed; 165.96 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

면역원

KLH-conjugated linear peptide corresponding to 20 amino acids from the C-terminal, cytoplasmic domain of mouse NR2B.

애플리케이션

Anti-NR2B, Cat. No. 06-600, is a rabbit polyclonal antibody that detects NR2B and is tested for use in Western Blotting.

Research Category
Neuroscience

Research Sub Category
Neurotransmitters & Receptors

Neurodegenerative Diseases

생화학적/생리학적 작용

This rabbit polyclonal antibody specifically detects NR2B. It targets an epitope within 20 amino acids from the C-terminal, cytoplasmic domain.

물리적 형태

Format: Purified

Protein A purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

제조 메모

Store at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance

분석 메모

Control
Mouse brain tissue

Evaluated by Western Blotting in rat brain microsomal preparation. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected NR2B in rat brain microsomal preparation.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

법적 정보

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1