382120

Histone Acetyltransferase Activator, CTB

The Histone Acetyltransferase Activator, CTB, also referenced under CAS 451491-47-7, modulates the biological activity of Histone. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 동의어(들): Histone Acetyltransferase Activator, CTB, EP300 Activator, E1A binding protein 300 Activator, N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, N-(4-Chloro-3-(trifluoromethyl)phenyl)-2-ethoxybenzamide, EP300 Activator, E1A binding protein 300 Activator
• 실험식(Hill 표기법): C₁₆H₁₃ClF₃NO₂
• CAS 번호: 451491-47-7
• Molecular Weight: 343.73
• MDL number: MFCD02356522
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥90% (HPLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; protect from light
• 색상: off-white
• solubility: ethanol: 5 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: FC(F)(F)c1c(ccc(c1)NC(=O)c2c(cccc2)OCC)Cl
• InChI: 1S/C16H13ClF3NO2/c1-2-23-14-6-4-3-5-11(14)15(22)21-10-7-8-13(17)12(9-10)16(18,19)20/h3-9H,2H2,1H3,(H,21,22)
• InChI key: YDXZSNHARVUYNM-UHFFFAOYSA-N

설명

일반 설명

A benzamide compound that activates the histone acetyltransferase (HAT) activity of p300/EP300/E1A binding protein 300 in a dose-dependent manner (~6-fold of basal HAT activity of recombinant human p300 toward purified HeLa core histones in the presence of 250 µM CTB). SERS spectrum indicates that CTB interacts with p300 preferentially via the amide groups of the α-helix and β-sheets, resulting in altered enzyme conformation, which presumably accounts for the increased enzymatic activity.

포장

Packaged under inert gas

제조 메모

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

기타 정보

Mantelingu, K., et al. 2007. J. Phys. Chem. B111, 4527.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Toxicity: Standard Handling (A)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2