생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
serum
항체 생산 유형
primary antibodies
클론
polyclonal
종 반응성
mouse, rat
제조업체/상표
Chemicon®
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
타겟 번역 후 변형
unmodified
유전자 정보
mouse ... Per2(18627)
1 of 4
이 품목 | AB5428P | AB2201 | SAB2101773 |
|---|---|---|---|
| biological source rabbit | biological source rabbit | biological source rabbit | biological source rabbit |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form serum | antibody form affinity purified immunoglobulin | antibody form serum | antibody form affinity isolated antibody |
| shipped in wet ice | shipped in dry ice | shipped in wet ice | shipped in wet ice |
| technique(s) western blot: suitable | technique(s) ELISA: suitable, western blot: suitable | technique(s) western blot: suitable | technique(s) western blot: suitable |
| Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per2(18627) | Gene Information mouse ... Per1(18626) | Gene Information human ... PER2(8864) |
일반 설명
Approx. 136 kDa Band may be observed at a much higher 200 kDa by the liver product depending on level of phophorylation and gel system used.
PER2 is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
면역원
Synthetic peptide.
애플리케이션
Anti-PER2 Antibody detects level of PER2 & has been published & validated for use in WB.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Circadian Rhythm & Sleep
Circadian Rhythm & Sleep
Western Blot Analysis:
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
C2C12 lysate was resolved by electrophoresis, transferred to PVDF membrane and probed with anti-PER2 (1:500 dilution of this lot). Proteins were visualized using a Donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence detection system.
생화학적/생리학적 작용
Cat. # AB2202 will recognize the N-terminus of PER2.
Reactivity with other species has not been determined.
물리적 형태
Serum with 0.05% NaN3
제조 메모
Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.
분석 메모
Control
C2C12 tissue lysate.
C2C12 tissue lysate.
Routinely evaluated by western blot on C2C12 lysate.
기타 정보
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
법적 정보
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
Jennifer Gile et al.
Current pharmaceutical design, 26(34), 4330-4337 (2020-04-16)
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B
Youli Yao et al.
Frontiers in physiology, 11, 294-294 (2020-05-12)
Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings
Tomoko Yoshikawa et al.
eNeuro, 8(5) (2021-08-14)
Biological neural networks operate at several levels of granularity, from the individual neuron to local neural circuits to networks of thousands of cells. The daily oscillation of the brain's master clock in the suprachiasmatic nucleus (SCN) rests on a yet
Peiyuan Qiu et al.
National science review, 6(1), 87-100 (2019-01-01)
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey
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