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Merck

AB5384

Anti-Nitric Oxide Synthase II Antibody

serum, Chemicon®

동의어(들):

NOS II, iNOS

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크기 선택

50 μL

₩632,853

₩632,853


예상 입고일2026년 1월 02일세부사항


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제품정보 (DICE 배송 시 비용 별도)

UNSPSC 코드:
12352203
eCl@ss:
32160702
NACRES:
NA.41

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기술 서비스
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도움 문의

생물학적 소스

rabbit

Quality Level

결합

unconjugated

항체 형태

serum

항체 생산 유형

primary antibodies

클론

polyclonal

종 반응성

human

제조업체/상표

Chemicon®

기술

immunohistochemistry: suitable
western blot: suitable

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

타겟 번역 후 변형

unmodified

유전자 정보

human ... NOS2(4843)

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목
N7782SAB5700636AB16301
antibody form

serum

antibody form

IgG fraction of antiserum

antibody form

affinity isolated antibody

antibody form

affinity purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

technique(s)

immunohistochemistry: suitable, western blot: suitable

technique(s)

microarray: suitable, western blot: 1:10,000 using cells extract of murine RAW 264.7 macrophages activated with LPS and IFN-γ.

technique(s)

western blot: 1:500-1:2000

technique(s)

immunocytochemistry: suitable, western blot: suitable

UniProt accession no.

P35228

UniProt accession no.

P29477

UniProt accession no.

P35228

UniProt accession no.

P29474

일반 설명

The inducible isoform of the enzyme nitric oxide synthase (iNOS, NOS-II) is synthesized by macrophages and many other cell types in response to proinflammatory cytokines and certain other stimuli, such as hypoxia and stress.

면역원

C-terminal 19 amino acid peptide from human chondrocyte nitric oxide synthase.

애플리케이션

Detect Nitric Oxide Synthase II using this Anti-Nitric Oxide Synthase II Antibody validated for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Oxidative Stress
Western blot: 1:1,000-1:2,500 (ECL).

Immunohistochemistry: 1:2,500-1:6,000 (ABC).

Optimal working dilutions must be determined by end user.

생화학적/생리학적 작용

Inducible nitric oxide synthase (iNOS, NOS-II). No cross-reaction with nNOS and eNOS by immunohistochemistry. AB5384 reacts with human glia and certain neurons in Alzheimer′s disease by immunohistochemistry.

물리적 형태

Rabbit serum. Liquid containing 0.05% sodium azide.

제조 메모

Maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.

법적 정보

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Imaging pulmonary inducible nitric oxide synthase expression with PET.
Huang, HJ; Isakow, W; Byers, DE; Engle, JT; Griffin, EA; Kemp, D; Brody, SL; Gropler et al.
Journal of Nuclear Medicine null
Jana Zschüntzsch et al.
Arthritis and rheumatism, 64(12), 4094-4103 (2012-09-04)
In sporadic inclusion body myositis (IBM), inflammation and accumulation of β-amyloid-associated molecules cause muscle fiber damage. We undertook this study to determine why intravenous immunoglobulin (IVIG) and prednisone are not effective in sporadic IBM despite their effectiveness in other inflammatory
Jonathon Chon Teng Chio et al.
Journal of neuroinflammation, 16(1), 141-141 (2019-07-11)
Spinal cord injury (SCI) is a condition with few effective treatment options. The blood-spinal cord barrier consists of pericytes, astrocytes, and endothelial cells, which are collectively termed the neurovascular unit. These cells support spinal cord homeostasis by expressing tight junction
Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron.
Haider, L; Simeonidou, C; Steinberger, G; Hametner, S; Grigoriadis, N; Deretzi, G; Kovacs et al.
Journal of Neurology, Neurosurgery, and Psychiatry null
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Schuh, C; Wimmer, I; Hametner, S; Haider, L; Van Dam, AM; Liblau, RS; Smith, KJ; Probert et al.
Acta neuropathologica null

관련 콘텐츠

"Redox reactions are powerful chemical processes that involve the reduction and oxidation of proteins and metabolites found in living things. The mechanisms that regulate them are key to maintaining homeostasis and the balance between good health and disease pathology. Oxidative stress is the state where the delicate balance of redox biology is upset, and the pathology of oxidative stress are the cellular consequences to such an imbalance."

"Aging: getting older, exhibiting the signs of age, the decline in the physical (and mental) well-being over time, leading to death. Since the beginning of time, man has been obsessed with trying to slow down, stop, or even reverse the signs of aging. Many have gone as far as experimenting with nutritional regimens, eccentric exercises, fantastic rituals, and naturally occurring or synthetic wonder-elements to evade the signs of normal aging. Biologically speaking, what is aging? And what does the latest research tell us about the possibility of discovering the elusive “fountain of youth”? Many advances in our understanding of aging have come from systematic scientific research, and perhaps it holds the key to immortality. Scientifically, aging can be defined as a systems-wide decline in organismal function that occurs over time. This decline occurs as a result of numerous events in the organism, and these events can be classified into nine “hallmarks” of aging, as proposed by López-Otin et al. (2013). Several of the pathologies associated with aging are a direct result of these events going to extremes and may also involve aberrant activation of proliferation signals or hyperactivity. The hallmarks of aging have been defined based on their fulfillment of specific aging related criteria, such as manifestation during normal aging, acceleration of aging if experimentally induced or aggravated, and retardation of aging if prevented or blocked, resulting in increased lifespan. The nine hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The biological processes underlying aging are complex. By understanding the hallmarks in greater detail, we can get closer to developing intervention strategies that can make the aging process less of a decline, and more of a recline."

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