MABC582

Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1

clone 11D12.1, from mouse

• 동의어(들): Baculoviral IAP repeat-containing protein 3, Apoptosis inhibitor 2, API2, C-IAP2, IAP homolog C, Inhibitor of apoptosis protein 1, IAP-1, hIAP-1, hIAP1, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1, hIAP-1/BIRC3
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 11D12.1, monoclonal
• 종 반응성: human
• 기술: western blot: suitable
• 동형: IgG1κ
• NCBI 수납 번호: NP_001156
• UniProt 수납 번호: Q13489
• 배송 상태: dry ice
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... BIRC3(330)

설명

일반 설명

Baculoviral IAP repeat-containing protein 3 (UniProt Q13489; also known as API2, Apoptosis inhibitor 2, Baculoviral IAP repeat-containing 3, c-IAP2, hIAP-1, hIAP1, IAP homolog C, IAP-1, Inhibitor of apoptosis protein 1, Mammalian IAP homolog C, RING finger protein 49, TNFR2-TRAF-signaling complex protein 1) is encoded by the BIRC3 (also known as API2, AIP1, IAP1, HAIP1, HIAP1, MALT2, MIHC, RNF49) gene (Gene ID 330) in human. hIAP-1 (c-IAP2) belongs to the inhibitor of apoptosis (IAP) family of proteins characterized by the presence of at least one baculoviral IAP repeat (BIR) domain. hIAP-1 (c-IAP2 contains three BIR (BIR1/2/3) domains, followed by an UBA (ubiquitin-associated), a CARD (caspase activation and recruitment domain), and a RING (really interesting new gene) domain. The BIR domains mediate hIAP-1 interaction with various binding partners, such as caspases, other IAP family members, and receptor-associated complexes. The RING domain and its associated E3 ligase mediates not only the ubiqutination of substrate proteins, such as caspase-3, caspase-7, SMAC/DIABLO, but also self-ubiquitylation. The UBA domain enables hIAP-1 to engage protein complexes containing poly-ubiquitylated protein(s).

~60 kDa observed

면역원

GST-tagged recombinant protein corresponding to the BIR 1/2 of human hIAP-1/BIRC3.

애플리케이션

Detect BIRC3 using this mouse monoclonal Anti-hIAP-1/BIRC3 Antibody, clone 11D12.1, Cat. No. MABC582, validated for use in Western Blotting.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

Western Blotting Analysis: 1.0 µg/mL from a representative lot detected hIAP-1/BIRC3 in 10 µg of TF-1, Jurkat, and Molt-4 cell lysate.

물리적 형태

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

제조 메모

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Evaluated by Western Blotting in K562 cell lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected hIAP-1/BIRC3 in 10 µg of K562 cell lysate.

기타 정보

Concentration: Please refer to lot specific datasheet.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable