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Merck

M003

R-(−)-Deprenyl hydrochloride

≥98% (HPLC), MAO-B inhibitor, powder

동의어(들):

(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride, R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride, Selegiline hydrochloride

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크기 선택

250 MG

₩182,700

1 G

₩548,506

₩182,700

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):
C13H17N · HCl
CAS 번호:
14611-52-0
Molecular Weight:
223.74
UNSPSC Code:
12352200
PubChem Substance ID:
24278577
NACRES:
NA.77
MDL number:
MFCD00069299

주요 문서

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제품 이름

R-(−)-Deprenyl hydrochloride, powder, ≥98% (HPLC)

SMILES string

Cl[H].C[C@H](Cc1ccccc1)N(C)CC#C

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

InChI key

IYETZZCWLLUHIJ-UTONKHPSSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]25/D −10.8°, c = 6.48 in H2O(lit.)

color

white

mp

141-142  °C

solubility

H2O: >10 mg/mL

originator

Sanofi Aventis

Quality Level

100

Gene Information

human ... MAOB(4129)

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관련 카테고리

유사한 품목 비교

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차이점 표시

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이 품목
D3630D7071P8013
R-(−)-Deprenyl hydrochloride powder, ≥98% (HPLC)

Sigma-Aldrich

M003

R-(−)-Deprenyl hydrochloride

Diphenhydramine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

D3630

Diphenhydramine hydrochloride

Dapoxetine hydrochloride ≥98% (HPLC)

Sigma-Aldrich

D7071

Dapoxetine hydrochloride

Pargyline hydrochloride

Sigma-Aldrich

P8013

Pargyline hydrochloride

form

powder

form

powder

form

powder

form

powder or crystals

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

98% (TLC)

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

solubility

H2O: >10 mg/mL

solubility

-

solubility

DMSO: ≥20 mg/mL

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

color

white

color

-

color

white

color

-

originator

Sanofi Aventis

originator

Johnson & Johnson

originator

Eli Lilly

originator

-

Biochem/physiol Actions

Selective MAO-B inhibitor; anti-Parkinsonian agent.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

저장 등급

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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시험 성적서(COA)

Lot/Batch Number
0000477504
0000477504
0000340007
0000340007
0000340006

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COA 검색

이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Michael M Monaghan et al.
Neuro-degenerative diseases, 7(1-3), 153-159 (2010-03-04)
Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. The purpose of the
Dominic Lomiwes et al.
Journal of agricultural and food chemistry, 72(30), 16777-16789 (2024-07-19)
Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the
Olivia J Kalimon et al.
Experimental neurology, 363, 114356-114356 (2023-02-26)
Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane that metabolizes amine substrates like serotonin, norepinephrine and dopamine. MAO inhibitors (MAOIs) are frequently utilized to treat disorders such as major depression or Parkinson's disease (PD), though their
Hojae Lee et al.
Nature neuroscience, 24(12), 1673-1685 (2021-11-17)
Amyotrophic lateral sclerosis (ALS) is a devastating disorder in which motor neurons degenerate, the causes of which remain unclear. In particular, the basis for selective vulnerability of spinal motor neurons (sMNs) and resistance of ocular motor neurons to degeneration in
J W Tetrud et al.
Science (New York, N.Y.), 245(4917), 519-522 (1989-08-04)
The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's disease, can be fully prevented in experimental animals by inhibiting monoamine oxidase B. On the basis of this observation, a double-blind, placebo-controlled study in patients with early
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