M9411
Myristicin from parsley leaf oil
≥85% (HPLC), oil
동의어(들):
4-Methoxy-6-(2-propenyl)-1,3-benzodioxole
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C11H12O3
CAS 번호:
Molecular Weight:
192.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
210-146-9
MDL number:
다음으로 건너뛰기
제품 이름
Myristicin from parsley leaf oil, ≥85% (HPLC), oil
InChI key
BNWJOHGLIBDBOB-UHFFFAOYSA-N
InChI
1S/C11H12O3/c1-3-4-8-5-9(12-2)11-10(6-8)13-7-14-11/h3,5-6H,1,4,7H2,2H3
SMILES string
COc1cc(CC=C)cc2OCOc12
assay
≥85% (HPLC)
form
oil
color
clear light yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
1 of 4
이 품목 | 09237 | W355801 | PHL80886 |
|---|---|---|---|
| form oil | form - | form - | form liquid |
| assay ≥85% (HPLC) | assay ≥97.0% (GC) | assay ≥89% | assay ≥90.0% (GC) |
| application(s) metabolomics | application(s) food and beverages | application(s) flavors and fragrances | application(s) - |
| Quality Level 200 | Quality Level 100 | Quality Level 400 | Quality Level - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C |
| color clear light yellow | color - | color - | color - |
Application
Myristicin from parsley leaf oil has been used to study competitive and uncompetitive inhibition of ACP (acid phosphatase) and ALP (alkaline phosphatase).[1]
Biochem/physiol Actions
Myristicin induces the expression of glutathione S-transferase and cytochrome P450 (Cyp1a-1) in liver cells. May enhance detoxification of carcinogenic substances.
General description
Myristicin, a phenylpropene, is an essential oil component.[2] It has anticholinergic and psychotropic activities.[3] Myristicin blocks cytochrome P450 monooxygenases, which detoxifies furanocoumarins.[2] It functions as a serotonin receptor agonist and hallucinogenic agent.[3] Myristicin stimulates glutathione S-transferase activity and might function as a chemopreventive agent.[4] It acts as a precursor for the metabolite 3,4- methylenedioxymethamphetamine (MDMA).[5]
signalword
Warning
hcodes
Hazard Classifications
STOT SE 3
target_organs
Central nervous system
저장 등급
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type ABEK (EN14387) respirator filter
H G Jeong et al.
Biochemical and biophysical research communications, 233(3), 619-622 (1997-04-28)
Mouse hepatoma Hepa-1c1c7 (Hepa-1) cells were treated with myristicin to assess the role of myristicin in the process of Cyp1a-1 induction. Treatment of Hepa-1 cells with myristicin increased Cyp1a-1 transcription in a dose-dependent manner as shown by analysis of 7-ethoxyresorufin
Myristicin: a potential cancer chemopreventive agent from parsley leaf oil
Zheng GQ, et al.
Journal of Agricultural and Food Chemistry, 40(1), 107-110 (1992)
H G Jeong et al.
Biochemical and biophysical research communications, 217(3), 966-971 (1995-12-26)
The effect of myristicin on the expression of liver cytochrome P450s and its mRNA levels was examined in rats. Treatment of rats with myristicin (i.p., 500 mumol/kg) caused 2-20 fold increases in liver P450 1A1/2, 2B1/2, and 2E1 enzyme activities
Allelochemical induction of cytochrome P450 monooxygenases and amelioration of xenobiotic toxicity in Helicoverpa zea
Zeng RS, et al.
Journal of Chemical Ecology, 33(3), 449-449 (2007)
G Q Zheng et al.
Carcinogenesis, 13(10), 1921-1923 (1992-10-01)
Glutathione S-transferase (GST) assay-guided fractionation of parsley leaf oil from the edible plant Petroselinum sativum Hoffm. (Umbelliferae) led to the isolation of myristicin. Myristicin showed high activity as an inducer of the detoxifying enzyme GST in the liver and small
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