SML1085
Retro-2
≥98% (HPLC), endosome-to-Golgi retrograde transport inhibitor, powder
동의어(들):
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
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제품정보 (DICE 배송 시 비용 별도)
실험식(Hill 표기법):
C19H16N2OS
CAS 번호:
Molecular Weight:
320.41
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
다음으로 건너뛰기
제품 이름
Retro-2, ≥98% (HPLC)
Quality Level
분석
≥98% (HPLC)
양식
powder
색상
white to beige
solubility
DMSO: 10 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
O=C1C2=CC=CC=C2NC(C3=CC=C(C)S3)N1C4=CC=CC=C4
InChI
1S/C19H16N2OS/c1-13-11-12-17(23-13)18-20-16-10-6-5-9-15(16)19(22)21(18)14-7-3-2-4-8-14/h2-12,18,20H,1H3
InChI key
BOAPXDSRULBILC-UHFFFAOYSA-N
1 of 4
이 품목 | SML1184 | SML0140 | L2545 |
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear (warmed) | solubility DMSO: 5 mg/mL, clear (warmed) | solubility DMSO: >5 mg/mL | solubility DMSO: >20 mg/mL |
| color white to beige | color white to beige | color white to off-white | color off-white |
애플리케이션
Retro-2 has been used to estimate retrograde trafficking of Shiga toxin subunit B (STxB)-Cy3.[1]
생화학적/생리학적 작용
Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps.
Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Zhouguang Jiao et al.
Journal of applied toxicology : JAT, 40(10), 1440-1450 (2020-06-01)
The current study explores the detoxification effect of Retro-2 on ricin toxin (RT) cytotoxicity, as well as the mechanisms underlying such effects, to provide a basis for follow-up clinical applications of Retro-2. The mouse-derived mononuclear/macrophage cell line, RAW264.7, was used
Structural insights into Legionella RidL-Vps29 retromer subunit interaction reveal displacement of the regulator TBC1D5.
Barlocher K, et al.
Nature Communications, 8(1), 1543-1543 (2017)
Giulia Tebaldi et al.
Journal of virology, 94(24) (2020-10-09)
Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs.
Sandrine Cojean et al.
PLoS neglected tropical diseases, 14(7), e0008396-e0008396 (2020-07-30)
The parasitophorous vacuoles (PVs) that insulate Leishmania spp. in host macrophages are vacuolar compartments wherein promastigote forms differentiate into amastigote that are the replicative form of the parasite and are also more resistant to host responses. We revisited the biogenesis
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