SML2257

IBR2

Name: IBR2
Brand: SIGMA
Price: 122105 KRW

≥98% (HPLC)

동의어(들):

(1R)-1,2-Dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]isoquinoline, (R)-2-(benzylsulfonyl)-1-(1H-indol-3-yl)-1,2-dihydroisoquinoline, Isoquinoline, 1,2-dihydro-1-(1H-indol-3-yl)-2-[(phenylmethyl)sulfonyl]-, (1R)-

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크기 선택

5 MG

₩122,105

25 MG

₩492,884

₩122,105

구입 가능 여부는 고객센터에 문의하십시오.

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제품정보 (DICE 배송 시 비용 별도)

실험식(Hill 표기법):

C₂₄H₂₀N₂O₂S

CAS 번호:

952739-54-7

Molecular Weight:

400.49

UNSPSC Code:

12352200

NACRES:

NA.77

주요 문서

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도움 문의

제품 이름

IBR2, ≥98% (HPLC)

InChI key

YCOHEPDJLXZVBZ-XMMPIXPASA-N

SMILES string

O=S(N1[C@@H](C2=CNC3=C2C=CC=C3)C4=CC=CC=C4C=C1)(CC5=CC=CC=C5)=O

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

유사한 품목 비교

전체 비교 보기

차이점 표시

1 of 4

이 품목	SML2769	SML3126	SML0412
Sigma-Aldrich SML2257 IBR2	Sigma-Aldrich SML2769 ASS234	Sigma-Aldrich SML3126 BI-2852	Sigma-Aldrich SML0412 IM-54
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 5 mg/mL (clear solution)
color white to beige	color white to beige	color white to beige	color light orange to dark orange

Biochem/physiol Actions

IBR2 is a cell penetrant, potent and specific RAD51 inhibitor that inhibits RAD51-mediated DNA double-strand break repair and enhances cytotoxicity of multiple anticancer agents with disparate biochemical targets including the Bcr-Abl inhibitor imatinib and multiple kinase inhibitor regorafenib. IBR2 disrupts RAD51 multimerization, accelerates proteasome-mediated RAD51 protein degradation, reduces ionizing radiation-induced RAD51 foci formation, inhibits cancer cell growth and induces apoptosis.

cell penetrant, potent and specific RAD51 inhibitor

저장 등급

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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시험 성적서(COA)

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문서 라이브러리 방문

A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia.

Jiewen Zhu et al.

EMBO molecular medicine, 5(3), 353-365 (2013-01-24)

RAD51 recombinase activity plays a critical role for cancer cell proliferation and survival, and often contributes to drug-resistance. Abnormally elevated RAD51 function and hyperactive homologous recombination (HR) rates have been found in a panel of cancers, including breast cancer and

Synthesis, molecular modeling, and biological evaluation of novel RAD51 inhibitors.

Jiewen Zhu et al.

European journal of medicinal chemistry, 96, 196-208 (2015-04-16)

RAD51 recombinase plays a critical role for cancer cell proliferation and survival. Targeting RAD51 is therefore an attractive strategy for treating difficult-to-treat cancers, e.g. triple negative breast cancers which are often resistant to existing therapeutics. To this end, we have

Synergistic Antiproliferative Activity of the RAD51 Inhibitor IBR2 with Inhibitors of Receptor Tyrosine Kinases and Microtubule Protein.

Peter J Ferguson et al.

The Journal of pharmacology and experimental therapeutics, 364(1), 46-54 (2017-10-25)

Although cancer cell genetic instability contributes to characteristics that mediate tumorigenicity, it also contributes to the tumor-selective toxicity of some chemotherapy drugs. This synthetic lethality can be enhanced by inhibitors of DNA repair. To exploit this potential Achilles heel, we

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자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..

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IBR2