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Merck

1.01587

L-Arginine

EMPROVE® EXPERT, Ph. Eur., ChP, JP, USP

Synonym(s):

L-Arginine, Arg

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About This Item

Empirical Formula (Hill Notation):
C6H14N4O2
CAS Number:
74-79-3
Molecular Weight:
174.20
MDL number:
MFCD00002635
UNSPSC Code:
12352209
EC Index Number:
200-811-1

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Agency

ChP
JP
Ph. Eur.
USP

Quality Level

500

product line

EMPROVE® EXPERT

form

solid

pH

11.4 (20 °C, 100 g/L in H2O)

mp

238 °C (decomposition)

application(s)

liquid formulation
parenterals
pharma/biopharma processes
pharmaceutical

storage temp.

2-30°C

SMILES string

[N+H3]C(CCCN=C(N)N)C(=O)[O-]

InChI

1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)

InChI key

ODKSFYDXXFIFQN-UHFFFAOYSA-N

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Arginine has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression, viscosity reduction, and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine Emprove® Expert is suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Articles

Viscosity Reduction in High Concentration TFF

This overview describes how use of viscosity-reducing excipients can address viscosity challenges in high concentration tangential flow filtration (TFF) and improve process economics.

Use of Stabilizers and Surfactants to Prevent Protein Aggregation

This article outlines critical factors in long-term stability of proteins, and how different stabilizers protect again mechanical and thermal stress.

Related Content

Formulation

Learn more on mAb subcutaneous or intravenous formulation, and the relevant associated products, including excipients.

User Guide - Experimental Procedures to Evaluate the Viscosity Reduction Platform

User Guide on Experimental Procedures to evaluate the viscosity reduction platform.

バイオ医薬品製造用製品ガイド
 Viscosity-Reducing Excipients for Protein Formulation
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