This product is shipped at ambient temperature. This material is lyophilized from a solution containing sodium phosphate, pH 6.5. It may be reconstituted in approximately 80 ul water per 25 ug vial. Activation is not necessary.
C8696
Cathepsin D from human liver
lyophilized powder, ≥250 units/mg protein (E1%/280)
Iniciar sesión para ver los precios por organización y contrato.
Seleccione un Tamaño
Cambiar Vistas
| Talla/SKU | Disponibilidad | Precio |
|---|
Acerca de este artículo
Número CAS:
UNSPSC Code:
12352204
NACRES:
NA.32
Número CE:
MDL number:
eCl@ss:
32160701
Specific activity:
≥250 units/mg protein (E1%/280)
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Servicio técnico
¿Necesita ayuda? Nuestro equipo de científicos experimentados está aquí para ayudarle.
Permítanos ayudarleform
lyophilized powder
Quality Segment
specific activity
≥250 units/mg protein (E1%/280)
mol wt
~45 kDa
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CTSD(1509)
General description
Cathepsin D is an aspartic protease, which is located in lysosomes. It is involved in protein catabolism and maintains hormone and antigen processing. Cathepsin D is implicated in neoplasia and neurodegenerative changes. It regulates lysosomal proteolysis and endogenous fibrinolysis.
Application
Biochem/physiol Actions
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer′s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts.
Physical form
Powder containing sodium phosphate buffer salt.
Other Notes
Contains α, β and γ isoenzymes as observed by isoelectric-focusing.
One unit will produce an increase in A280 of 1.0 in 30 min at pH 3.3 at 37 °C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path).
1 of 1
Este artículo | |||
|---|---|---|---|
| description lyophilized powder, ≥250 units/mg protein (E1%/280) | description clone CTD-19, purified from hybridoma cell culture | description for serum, plasma and cell culture supernatants | description ≥0.5 units/mg protein, solution |
| Gene Information human ... CTSD(1509) | Gene Information human ... CTSD(1509) | Gene Information human ... CTSD(1509) | Gene Information human ... CTSL1(1514) |
| specific activity ≥250 units/mg protein (E1%/280) | specific activity - | specific activity - | specific activity ≥0.5 units/mg protein |
| form lyophilized powder | form buffered aqueous solution | form - | form solution |
| UniProt accession no. | UniProt accession no. | UniProt accession no. - | UniProt accession no. |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt ~45 kDa | mol wt - | mol wt - | mol wt - |
Clase de almacenamiento
11 - Combustible Solids
WGK
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
Elija entre una de las versiones más recientes:
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
-
At what temperature is it shipped? How to reconstitute it? Is it active or to be activated?
1 answer-
Helpful?
-