E2387

5′-(N-Ethylcarboxamido)adenosine

powder

• Synonym(s): NECA
• Empirical Formula (Hill Notation): C₁₂H₁₆N₆O₄
• CAS Number: 35920-39-9
• Molecular Weight: 308.29
• Número MDL: MFCD00069195
• ID de la sustancia en PubChem: 24277684

Properties

• formulario: powder
• Nivel de calidad: 200
• color: white
• solubilidad: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL (Solutions may be stored for several days at 4 °C.); DMSO: 14 mg/mL (Solutions may be stored for several days at 4 °C.); 0.1 M HCl: 3.4 mg/mL (Solutions may be stored for several days at 4 °C.); H₂O: insoluble; ethanol: soluble (Solutions may be stored for several days at 4 °C.)
• temp. de almacenamiento: 2-8°C
• SMILES string: CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C12H16N6O4/c1-2-14-11(21)8-6(19)7(20)12(22-8)18-4-17-5-9(13)15-3-16-10(5)18/h3-4,6-8,12,19-20H,2H2,1H3,(H,14,21)(H2,13,15,16)/t6-,7+,8-,12+/m0/s1
• InChI key: JADDQZYHOWSFJD-FLNNQWSLSA-N
• Gene Information: human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140) ; rat ... Adora1(29290) , Adora2a(25369) , Adora2b(29316) , Adora3(25370)

Description

Descripción general

5′-(N-Ethylcarboxamido)adenosine stimulates vasodilation in the pulmonary circulation through A₂-adenosine-receptor activation.[1]

Aplicación

5′-(N-Ethylcarboxamido)adenosine has been used:

• for the purification of human adenosine A_2Areceptor (A_2AR) in decylmaltoside (DM)[2]
• to determine nonspecific binding of adenosine receptors[3]
• to investigate adenosine 2B receptor (RA2B) mechanism of action by competition assay[4]

Envase

50 mg in poly bottle

Acciones bioquímicas o fisiológicas

Potent adenosine receptor agonist with nearly equal affinity at A₁ and A₂ receptors.

Características y beneficios

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P301 + P310
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges