E9750

Estrone

≥99%

• Sinónimos: Folliculin, 1,3,5(10)-Estratrien-3-ol-17-one, 3-Hydroxy-1,3,5(10)-estratrien-17-one
• Empirical Formula (Hill Notation): C₁₈H₂₂O₂
• Número de CAS: 53-16-7
• Peso molecular: 270.37
• Beilstein: 1915077
• Número de EC: 200-164-5
• Número MDL: MFCD00003620
• ID de la sustancia en PubChem: 24278427
• NACRES: NA.77

Propiedades

• origen biológico: synthetic (organic)
• esterilidad: non-sterile
• ensayo: ≥99%
• formulario: powder
• mp: 258-260 °C (lit.)
• solubilidad: dioxane: 50 mg/mL, clear, colorless to very faintly yellow
• enviado en: ambient
• temp. de almacenamiento: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]1CCC2=O
• InChI: 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
• InChI key: DNXHEGUUPJUMQT-CBZIJGRNSA-N
• Gene Information: human ... ESR1(2099) , ESR2(2100) , ESRRA(2101) , ESRRB(2103) , HSD17B1(3292) , SERPINA6(866) ; mouse ... Esr1(13982) ; rat ... Esr1(24890)

Descripción

Descripción general

Estrone is a weak form of estrogen and exists as estrone sulphate. Estrone is a luteolytic estrogen produced by the corpus luteum. In the follicle, estrone is synthesized from androstenedione by the action of cytochrome P450 aromatase.

Aplicación

Estrone has been used:

• as medium supplement for hormone based degranulation studies of natural killer cells
• as an endocrine disrupting compound for screening bacterial biosensor in toxic water.
• as medium component for monitoring fatty acid synthase (FASN) activity in breast adenocarcinoma cell lines

Envase

1, 5, 25 g in glass bottle

500 mg in glass bottle

Acciones bioquímicas o fisiológicas

Estrone is an agonist for the estrogen receptor. The estradiol to estrone interconversion is favourable in menopause. Oral hormone replacement therapy (HRT) of estradiol-17β increases circulating levels of estrone.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H351 - H360FD - H362
• Consejos de prudencia: P202 - P260 - P263 - P264 - P270 - P308 + P313
• Clasificaciones de peligro: Carc. 2 - Lact. - Repr. 1A
• Código de clase de almacenamiento: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Punto de inflamabilidad F: Not applicable
• Punto de inflamabilidad C: Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges