SML0010

Sigma-Aldrich

LY-334370 hydrochloride hydrate

≥98% (HPLC), powder

Sinónimos:
4-Fluoro-N-[3-(1-methyl-4-piperidinyl)-1H-indol-5-yl]benzamide hydrochloride hydrate
Empirical Formula (Hill Notation):
C21H22FN3O · HCl · xH2O
Peso molecular:
387.88 (anhydrous basis)
MDL number:
PubChem Substance ID:
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Quality Level

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

H2O: ≥5 mg/mL (warmed)

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl.CN1CCC(CC1)c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23

InChI

1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H

InChI key

DGPDGAPZTPSHBL-UHFFFAOYSA-N

Application

LY-334370 hydrochloride hydrate may be used to study 5-HT 1F-mediated cell signaling.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

LY-334370 modulates the transmission in the mouse trigeminal system and inhibits the neuronal responses within rat Sp5C by inhibiting c-Fos activation. It shows efficacy in aborting migraine attacks.
LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point F

Not applicable

Flash Point C

Not applicable

Sandra A Filla et al.
Journal of medicinal chemistry, 46(14), 3060-3071 (2003-06-27)
Compound 1a (LY334370), a selective 5-HT(1F) receptor agonist (SSOFRA), inhibited dural inflammation in the neurogenic plasma protein extravasation model of migraine and demonstrated clinical efficacy for the acute treatment of migraine. Although 1a was greater than 100-fold selective over both...
D D Mitsikostas et al.
Cephalalgia : an international journal of headache, 22(5), 384-394 (2002-07-12)
In order to investigate the c-fos response within the trigeminal nucleus caudalis (Sp5C) after noxious meningeal stimulation, capsaicin (0.25, 0.5, 1 and 5 nmol) was administered intracisternally in urethane (1 g/kg) and alpha-chloralose (20 mg/kg) anaesthetized male mice. Capsaicin induced...

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