Merck
All Photos(1)

SML2234

Sigma-Aldrich

1S,3R-RSL 3

≥98% (HPLC)

All Photos(1)
Synonym(s):
(1S, 3R)-2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
Empirical Formula (Hill Notation):
C23H21ClN2O5
CAS Number:
1219810-16-8
Molecular Weight:
440.88
Número MDL:
MFCD30187526
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

−20°C

Compare Similar Items

View Full Comparison

1 of 4

This Item
A6478SML1948I117
1S,3R-RSL 3 ≥98% (HPLC)

Sigma-Aldrich

SML2234

1S,3R-RSL 3

(R,S)-AM1241 ≥98% (HPLC), solid

Sigma-Aldrich

A6478

(R,S)-AM1241

S1QEL1.1 ≥98% (HPLC)

Sigma-Aldrich

SML1948

S1QEL1.1

R(+)-IAA-94 ≥98% (HPLC), solid

Sigma-Aldrich

I117

R(+)-IAA-94

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

solid

color

white to beige

color

yellow

color

white to beige

color

white

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ~18 mg/mL at 60 °C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

Aplicación

1S,3R-RSL 3 has been used:
  • as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) lines
  • GPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in mice
  • as a ferroptosis inducer in HT-1080 cellsin cell viability assay

Acciones bioquímicas o fisiológicas

RSL3 is an inducer of ferroptosis. It acts by a different method than erastin to induce ferroptosis by inhibiting glutathione peroxidase 4 (GPX4).

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (Example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service