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SML2234

Sigma-Aldrich

1S,3R-RSL 3

≥98% (HPLC)

Synonym(s):
(1S, 3R)-2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
Empirical Formula (Hill Notation):
C23H21ClN2O5
CAS Number:
Molecular Weight:
440.88
Número MDL:
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

white to beige

solubilidad

DMSO: 2 mg/mL, clear

temp. de almacenamiento

−20°C

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1S,3R-RSL 3 ≥98% (HPLC)

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(R,S)-AM1241 ≥98% (HPLC), solid

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Sigma-Aldrich

I117

R(+)-IAA-94

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

solid

form

powder

form

solid

color

white to beige

color

yellow

color

white to beige

color

white

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: ~18 mg/mL at 60 °C

solubility

DMSO: 2 mg/mL, clear

solubility

H2O: 0.2 mg/mL, 0.1 M NaOH: 2.8 mg/mL, DMSO: >20 mg/mL, ethanol: 20 mg/mL, dilute aqueous acid: insoluble

storage temp.

−20°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

Aplicación

1S,3R-RSL 3 has been used:
  • as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) lines
  • GPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in mice
  • as a ferroptosis inducer in HT-1080 cellsin cell viability assay

Acciones bioquímicas o fisiológicas

RSL3 is an inducer of ferroptosis. It acts by a different method than erastin to induce ferroptosis by inhibiting glutathione peroxidase 4 (GPX4).

Código de clase de almacenamiento

11 - Combustible Solids

WGK

WGK 3

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable


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