Looking for a 5-HT7 radiotracer for positron emission tomography.

Looking for a 5-HT7 radiotracer for positron emission tomography.

Bioorganic & medicinal chemistry letters (2010-05-18)

Julien Andriès, Laëtitia Lemoine, Alice Mouchel-Blaisot, Sandrine Tang, Mathieu Verdurand, Didier Le Bars, Luc Zimmer, Thierry Billard

PMID20471259

RESUMEN

In search of a serotonin 5-HT(7) radiotracer for positron emission tomography, we developed 1-[2-[(2S)-1-(phenylsulfonyl)pyrrolidin-2-yl]ethyl]piperidin-4-yl 4-fluorobenzoate. After labeling in good yield with fluorine-18 via nitro for fluorine exchange, preliminary biological experiments with autoradiographies failed to evidence any specific 5-HT(7) receptor delineation.

MATERIALES

Número de producto

Marca

Descripción del producto

128384

Sigma-Aldrich

4-Fluorobenzoic acid, 98%

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418846

Sigma-Aldrich

4-Fluorobenzoic acid, 99%, purified by sublimation

En este momento no podemos mostrarle ni los precios ni la disponibilidad