05-780

Anti-Akt3/PKBγ Antibody, clone GMA104

Name: Anti-Akt3/PKBγ Antibody, clone GMA104
Brand: MM
Price: 463 EUR
Availability: InStock

clone GMA104, Upstate^®, from mouse

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100 μG

€463.00

Estimated to ship on10 November 2025Details

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About This Item

UNSPSC Code:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Key Documents

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biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified antibody

antibody product type

primary antibodies

clone

GMA104, monoclonal

species reactivity

human

manufacturer/tradename

Upstate^®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG2a

NCBI accession no.

NM_005465

UniProt accession no.

Q9Y243

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... AKT3(10000)

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This Item	07-383	05-796	04-1643
Sigma-Aldrich 05-780 Anti-Akt3/PKBγ Antibody, clone GMA104	Sigma-Aldrich 07-383 Anti-Akt3/PKBγ Antibody	Sigma-Aldrich 05-796 Anti-Akt1/PKBα Antibody, clone AW24, rabbit monoclonal	Sigma-Aldrich 04-1643 Rabbit Anti-Mouse IgG Antibody, clone RM104
species reactivity human	species reactivity human	species reactivity human, mouse, rat	species reactivity mouse
antibody form purified antibody	antibody form affinity purified immunoglobulin	antibody form purified antibody	antibody form purified antibody
clone GMA104, monoclonal	clone polyclonal	clone AW24, monoclonal	clone RM104, monoclonal
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
shipped in wet ice	shipped in dry ice	shipped in dry ice	shipped in wet ice
technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) immunoprecipitation (IP): suitable, western blot: suitable	technique(s) ELISA: suitable, western blot: suitable

General description

~60kDa

Immunogen

peptide corresponding to amino acids 119-131 (CSPTSQIDNIGEE) of human Akt3/PKBγ

Application

Research Category
Signaling

Research Sub Category
PI3K, Akt, & mTOR Signaling

This Anti-Akt3/PKBγ Antibody, clone GMA104 is validated for use in IP, WB for the detection of Akt3/PKBγ.

Biochem/physiol Actions

Predicted to cross-react with mouse and rat based on sequence homology.

RhoA

Physical form

Buffered solution containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4.

Format: Purified

Protein A purified

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

routinely evaluated by immunoblot on RIPA lysates from Jurkat or HL-60 cells

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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K-Ras(V12) differentially affects the three Akt isoforms in lung and pancreatic carcinoma cells and upregulates E-cadherin and NCAM via Akt3.

Rebekka Geißert et al.

Cell communication and signaling : CCS, 22(1), 85-85 (2024-01-31)

K-Ras is the most frequently mutated Ras variant in pancreatic, colon and non-small cell lung adenocarcinoma. Activating mutations in K-Ras result in increased amounts of active Ras-GTP and subsequently a hyperactivation of effector proteins and downstream signaling pathways. Here, we

Characterization of PDK2 activity against protein kinase B gamma.

Conrad P Hodgkinson et al.

Biochemistry, 41(32), 10351-10359 (2002-08-07)

Protein kinase B (PKB), also known as Akt, is a serine/threonine protein kinase controlled by insulin, various growth factors, and phosphatidylinositol 3-kinase. Full activation of the PKB enzyme requires phosphorylation of a threonine in the activation loop and a serine

MicroRNA-497 impairs the growth of chemoresistant neuroblastoma cells by targeting cell cycle, survival and vascular permeability genes.

Aroa Soriano et al.

Oncotarget, 7(8), 9271-9287 (2016-01-30)

Despite multimodal therapies, a high percentage of high-risk neuroblastoma (NB) become refractory to current treatments, most of which interfere with cell cycle and DNA synthesis or function, activating the DNA damage response (DDR). In cancer, this process is frequently altered

The Akt isoforms are present at distinct subcellular locations.

Santi, SA; Lee, H

American Journal of Physiology. Cell Physiology null

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