528824

PARP Inhibitor XIV

The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Synonym(s): PARP Inhibitor XIV, 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
• Empirical Formula (Hill Notation): C₁₅H₁₂N₂O₂
• CAS Number: 1104546-89-5
• Molecular Weight: 252.27
• MDL number: MFCD12912397
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥97% (sum of two isomers, HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: orange
• solubility: DMSO: 10 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [n]1(c(ccc1)\C=C2\c3c(cccc3)C(=O)NC\2=O)C
• InChI: 1S/C15H12N2O2/c1-17-8-4-5-10(17)9-13-11-6-2-3-7-12(11)14(18)16-15(13)19/h2-9H,1H3,(H,16,18,19)/b13-9-
• InChI key: BTYSIDSTHDDAJW-LCYFTJDESA-N

Description

General description

A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC₅₀ = 7.35; IC₅₀ = 45 nM) in a NAD⁺-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Eltze, T., et al. 2008. Mol. Pharmacol.74, 1587.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable