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Merck

B2635

Busulfan

analytical standard, for drug analysis

Synonym(s):

1,4-Butanediol dimethanesulfonate

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About This Item

Linear Formula:
CH3SO2O(CH2)4OSO2CH3
CAS Number:
Molecular Weight:
246.30
Beilstein:
1791786
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

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Quality Level

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

114-117 °C (lit.)

application(s)

forensics and toxicology
veterinary

format

neat

SMILES string

CS(=O)(=O)OCCCCOS(C)(=O)=O

InChI

1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

InChI key

COVZYZSDYWQREU-UHFFFAOYSA-N

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1 of 4

This Item
B1385B3022BP403
Busulfan British Pharmacopoeia (BP) Reference Standard

BP403

Busulfan

application(s)

forensics and toxicology
veterinary

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

application(s)

forensics and toxicology
veterinary

application(s)

pharmaceutical
pharmaceutical small molecule

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

grade

analytical standard, for drug analysis

grade

analytical standard, for drug analysis

grade

analytical standard, for drug analysis

grade

pharmaceutical primary standard

format

neat

format

neat

format

neat

format

neat

mp

114-117 °C (lit.)

mp

-

mp

-

mp

114-117 °C (lit.)

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

-

General description

Busulfan is a bifunctional alkylating agent[1], which may find application in the treatment of chronic granulocytic leukemia.[1]

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1A - Muta. 1B - Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Blood and Marrow Stem Cell Transplantation: Principles, Practice, and Nursing Insights (1997)
Moustapha Hassan et al.
Pharmacogenomics, 14(1), 75-87 (2012-12-21)
Hematopoietic stem cell transplantation (HSCT) is a curative treatment for several malignant and nonmalignant disorders. Busulfan (Bu) and cyclophosphamide (Cy) are the most commonly used alkylators in high-dose pretransplant conditioning for HSCT; a treatment that is correlated with drug-related toxicity
Donna Reece et al.
The oncologist, 18(5), 611-618 (2013-05-01)
Multiple myeloma is a malignancy of B cells characterized by accumulation of abnormal plasma cells in the bone marrow. In the past 20 years, the use of high-dose therapies and novel agents has resulted in significant and meaningful improvements in
M Hassan et al.
Leukemia & lymphoma, 22(5-6), 395-407 (1996-08-01)
Busulfan as a high-dose therapy is an important component of many of the myeloablative regimens for both allogeneic and autologous bone marrow transplantation (BMT) in adults and children. During the last decade, several studies have shown a wide inter- and
Dharma Choudhary et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(3), 492-495 (2012-11-20)
Hematopoietic stem cell transplantation (HSCT) is the definite treatment for patients with thalassemia major. A busulfan (Bu) and cyclophosphamide (Cy)-based regimen has been the standard myeloablative chemotherapy, but it is associated with higher treatment-related toxicity, particularly in patients classified as

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. SDSに保管温度や溶解条件等が見当たらないので教えていただけますでしょうか。また、現在HPLCの標準物質として使用しており、MeOHに溶解後、乾固凍結、使用時に再溶解しています。溶解後の保存についても最適な方法(乾固の有無・温度・期間)を教えてください。

    1 answer
    1. The neat product is to be stored at room temperature. Busulfan is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of busulfan in these solvents is approximately 16.7 mg/ml. No solution stability studies are performed for this compound but the literature recommends using the prepared solution within 24 hours.

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