The potency of T5639 is for the free form of Ticarcillin per USP.
T5639
Ticarcillin disodium salt
Synonym(s):
(2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt
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About This Item
Empirical Formula (Hill Notation):
C15H14N2Na2O6S2
CAS Number:
Molecular Weight:
428.39
MDL number:
UNSPSC Code:
51282427
PubChem Substance ID:
NACRES:
NA.85
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biological source
semisynthetic
Quality Level
form
powder or crystals
color
white to light yellow
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
Mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
SMILES string
[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O
InChI
1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1
InChI key
ZBBCUBMBMZNEME-QBGWIPKPSA-L
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Related Categories
1 of 4
This Item | T2820 | C5793 | C8145 |
|---|---|---|---|
| antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria |
| mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes | mode of action cell wall synthesis | interferes |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| form powder or crystals | form powder or crystals | form powder or crystals | form powder or crystals |
| storage temp. 2-8°C | storage temp. - | storage temp. 2-8°C | storage temp. 2-8°C |
| biological source semisynthetic | biological source - | biological source - | biological source - |
General description
Chemical structure: ß-lactam
Application
Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy[1]. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis[2].
Biochem/physiol Actions
Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by ß-lactamases[1].
Packaging
1G
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.
Other Notes
β-Lactam antibiotic
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
Target Organs
Respiratory system
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Müserref Tatman-Otkun et al.
BMC microbiology, 5, 24-24 (2005-05-11)
Stenotrophomonas maltophilia is inherently resistant to many antimicrobials. So far, antimicrobial susceptibility tests for S. maltophilia have not been fully standardized. The purpose of the study was to compare the susceptibility of S. maltophilia isolates against seven different antimicrobials using
R N Brogden et al.
Drugs, 20(5), 325-352 (1980-11-01)
Ticarcillin is a semisynthetic penicillin for parenteral administration. The antibacterial activity of ticarcillin is similar to that of carbenicillin except that it is two to four times more active in vitro against Pseudomonas aeruginosa, generally less active against Gram-positive cocci
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Product Information Sheet
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Is the potency indicated for T5639 (CAS 4697-14-7) to be interpreted as the potency for the free form of Ticarcillin, or is it the potency of the salt form?
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